pivoine
Paeonia · Paeony
Paeonia is a traditional medicinal plant with roots in East Asian herbal medicine. Traditionally, it has been used for various conditions such as menstrual cramps and liver disorders, though specific uses vary among different traditions. Scientific evidence suggests that paeonol from Paeonia lactiflora can suppress prostate cancer progression by regulating the miR-145-5p/GOLM1 axis. Additionally, paeoniflorin has shown potential in reducing inflammation associated with osteoarthritis through upregulating SOCS3 expression in macrophages. Extracellular vesicles derived from Paeonia lactiflora have been found to improve diabetic peripheral neuropathy by modulating CCL21/CCR7 signaling and reducing Schwann cell injury and neuroinflammation. Albiflorin, another compound from the plant, has demonstrated multiple pharmacological activities including anti-inflammatory, neuroprotective, and hepatoprotective effects, though its oral bioavailability remains a challenge for therapeutic applications. No major safety issues or drug interactions have been recorded for Paeonia.
- Meilleure preuve
- D
- Précautions
- —
Information uniquement. L'usage traditionnel ne signifie pas une efficacité prouvée. Les preuves et la sécurité varient — consultez les sources citées.
Ce que dit la science
- Le paeonol réprime la progression du cancer de la prostate en régulant l'axe miR-145-5p/GOLM1.
- Le paeoniflorine a upregulated l'expression de SOCS3 dans les macrophages, potentiellement réduisant l'inflammation dans un modèle de OA chez la souris.
- Vesicules extracellulaires dérivées de Paeonia lactiflora améliorent la neuropathie périphérique diabétique en modulant le signalisation CCL21/CCR7, réduisant l'innommation cellulaire de Schwann et l'inflammation neurologique.
- L'albiflorine a montré de multiples activités pharmacologiques, notamment des effets antirétroviraux, neuroprotecteurs et hépatoprotecteurs, mais l'absorption orale optimale reste incertaine.
- Trois cultivars, «Red Charm», «Bartzella» et «Sarah Bernhardt», ont montré une tolérance salinée relative plus forte sous des conditions de stress sévères.
- Three novel monoterpenoids were isolated from Paeonia lactiflora roots and showed significant neuroprotective effects against H2O2-induced injury in PC12 cells.
Frequently asked questions
What is pivoine?
pivoine (Paeonia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about pivoine?
6 sourced findings are recorded for pivoine; the strongest carries evidence grade D. For example: Le paeonol réprime la progression du cancer de la prostate en régulant l'axe miR-145-5p/GOLM1.
How strong is the evidence for pivoine?
The strongest finding for pivoine carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is pivoine safe? What are the side effects?
No major safety issues are recorded for pivoine in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does pivoine interact with medications?
No drug interactions are recorded for pivoine in our sources. This does not rule them out — check with a pharmacist.
What are the common names of pivoine?
pivoine is also known as: Paeony, Пион.
Is pivoine a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Paeonia lactiflora-derived extracellular vesicles ameliorate diabetic peripheral neuropathy by modulating chemokine-guided immune trafficking in peripheral nerves. literature abstract metadata
- T2 Monoterpenoids from the roots of Paeonia lactiflora Pall. and their neuroprotective activity. literature abstract metadata
- T2 Paeoniflorin elevates the expression of SOCS3 in macrophages to prevent MIA-induced osteoarthritis in mice. literature abstract metadata
- T2 Paeonol inhibits prostate cancer progression via the miR-145-5p/GOLM1 axis. literature abstract metadata
- T2 Evaluation and physiological response of peony (Paeonia lactiflora Pall.) under salt stress. literature abstract metadata
- T2 A Review of the Pharmacodynamics and Pharmacokinetics of Albiflorin. literature abstract metadata