Aconite
Aconitum
Aconitum 是一种传统上在东方和西方各种草药实践中广泛使用的植物属，特别是在中医中。Aconitum 的具体传统用途尚未有广泛的文献记录。科学研究表明，Aconitum 的二萜生物碱具有潜在的抗炎作用，这可能是通过调节 Caspase-3 信号传导和维持线粒体功能实现的。这些化合物的生物合成途径也已阐明，确定了涉及乙醇胺整合到二萜骨架中的关键酶促步骤。此外，研究表明 Aconitum 提取物在寒冷暴露前给药时可能增强棕色脂肪组织的产热作用，从而提高在这种条件下生存的可能性。值得注意的是，迄今为止尚未记录有关 Aconitum 的重大安全问题或药物相互作用。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- LA预处理通过调节凋亡相关信号传导和维持线粒体功能，减少了TNF-α诱导的SH-SY5Y细胞凋亡。
- 研究确定了六步酶促步骤参与二萜生物碱的合成，包括将乙醇胺整合到二萜骨架中的还原酶。
- 研究确定了12个二萜生物碱标记物，与主要根（CHW）和侧根（FZ）中黄连的抗炎活性差异有关。
- 单次预防性给予 Shenfu 汤剂（SFD）1:1 浓度和每公斤体重 1.35 克，在接触冷水之前，显著延长大鼠存活时间，通过增强棕色脂肪组织的产热作用。
- Qishen膏通过上调心肌驻留巨噬细胞中的Cx43改善了心力衰竭小鼠的心脏传导和功能。
Frequently asked questions
What is Aconite?
Aconite (Aconitum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Aconite?
5 sourced findings are recorded for Aconite; the strongest carries evidence grade D. For example: LA预处理通过调节凋亡相关信号传导和维持线粒体功能，减少了TNF-α诱导的SH-SY5Y细胞凋亡。
How strong is the evidence for Aconite?
The strongest finding for Aconite carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Aconite safe? What are the side effects?
No major safety issues are recorded for Aconite in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Aconite interact with medications?
No drug interactions are recorded for Aconite in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Aconite?
Aconite is also known as: Борец, Aconit.
Is Aconite a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Bioactive Constituents and Therapeutic Mechanisms of Shenfu Decoction in a Rat Model of Seawater-Immersion-Induced Accidental Hypothermia. literature abstract metadata
- T2 Novel insights into anti-inflammatory activity-related metabolic markers and biosynthetic regulatory mechanisms between principal and lateral roots of Aconitum carmichaelii Debx. via integrated metabolomics and transcriptomics. literature abstract metadata
- T2 Characterization of the Entry Steps in Diterpenoid Alkaloid Biosynthesis. literature abstract metadata
- T2 Lappaconitine protects SH-SY5Y cells from TNF-α-induced mitochondrial apoptosis by blocking the Bax-dependent Caspase-3 signaling pathway. literature abstract metadata
- T2 Qishen Paste Improves Cardiac Conduction in Heart Failure by Regulating Cardiac Resident Macrophage Connexin43. literature abstract metadata