Aconite
Aconitum
Aconitum，一种常见于亚洲和欧洲山区的开花植物属，在各种传统医学形式中被广泛使用，但没有特定的传统用途。科学研究表明，用Aconitum（LA）碱类进行预处理可以减少TNF-α诱导的SH-SY5Y细胞凋亡，通过调节信号通路并保持线粒体功能，显示出潜在的抗炎作用。此外，研究还发现了六步酶促途径参与二萜生物碱的合成，包括将乙醇胺整合到二萜骨架中的还原酶，从而为其生物活性做出贡献。该研究还发现12个与Aconitum carmichaelii主根和侧根之间抗炎活性差异相关的二萜生物碱标记物。在另一项研究中，在冷海水暴露前给予单次预防性施用Shenfu煎剂（SFD）显著延长了大鼠的存活时间，通过增强棕色脂肪组织的产热作用。尚未记录到该植物的重大安全问题或药物相互作用。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- LA预处理通过调节凋亡相关信号传导和维持线粒体功能，减少了TNF-α诱导的SH-SY5Y细胞凋亡。
- 研究确定了六步酶促步骤参与二萜生物碱的合成，包括将乙醇胺整合到二萜骨架中的还原酶。
- 研究确定了12个二萜生物碱标记物，与主要根（CHW）和侧根（FZ）中黄连的抗炎活性差异有关。
- 单次预防性给予 Shenfu 汤剂（SFD）1:1 浓度和每公斤体重 1.35 克，在接触冷水之前，显著延长大鼠存活时间，通过增强棕色脂肪组织的产热作用。
- Qishen膏通过上调心肌驻留巨噬细胞中的Cx43改善了心力衰竭小鼠的心脏传导和功能。
Frequently asked questions
What is Aconite?
Aconite (Aconitum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Aconite?
5 sourced findings are recorded for Aconite; the strongest carries evidence grade D. For example: LA预处理通过调节凋亡相关信号传导和维持线粒体功能，减少了TNF-α诱导的SH-SY5Y细胞凋亡。
How strong is the evidence for Aconite?
The strongest finding for Aconite carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Aconite safe? What are the side effects?
No major safety issues are recorded for Aconite in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Aconite interact with medications?
No drug interactions are recorded for Aconite in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Aconite?
Aconite is also known as: Борец, Aconit.
Is Aconite a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Bioactive Constituents and Therapeutic Mechanisms of Shenfu Decoction in a Rat Model of Seawater-Immersion-Induced Accidental Hypothermia. literature abstract metadata
- T2 Novel insights into anti-inflammatory activity-related metabolic markers and biosynthetic regulatory mechanisms between principal and lateral roots of Aconitum carmichaelii Debx. via integrated metabolomics and transcriptomics. literature abstract metadata
- T2 Characterization of the Entry Steps in Diterpenoid Alkaloid Biosynthesis. literature abstract metadata
- T2 Lappaconitine protects SH-SY5Y cells from TNF-α-induced mitochondrial apoptosis by blocking the Bax-dependent Caspase-3 signaling pathway. literature abstract metadata
- T2 Qishen Paste Improves Cardiac Conduction in Heart Failure by Regulating Cardiac Resident Macrophage Connexin43. literature abstract metadata