Bitter orange
Citrus × aurantium
Citrus × aurantium，又称苦橙，是一种起源于东南亚和地中海的传统植物。传统上，它在特定的医疗实践或记录的传统中并未广泛使用。科学研究表明，苦橙果实精油中发现的化合物具有与标准抑制剂相似的NF-κB和p38 MAPK途径的抑制潜力。此外，苦橙蜂蜜表现出剂量依赖性的肠道蠕动增强和减少炎症作用，通过调节TORC1通路在Drosophila模型中实现。另一项研究显示，CAVAE（Citrus aurantium提取物）有可能通过调节PI3K/AKT和Wnt-3a/β-catenin途径缓解糖尿病性骨质疏松症。此外，与苦橙精油或纳米乳液结合的γ射线显著增加了储粮昆虫的死亡率，而不会损害种子发芽。尚未记录到这种植物的重大安全问题，也没有报告药物相互作用。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 研究发现柑橘属Citrus aurantium果实精油中存在几种化合物，其对NF-κB和p38 MAPK的抑制潜力与标准抑制剂相当。
- 柑橘 Aurantium 蜂蜜剂量依赖性地增强了果蝇模型中的肠道运动并减少了通过调节TORC1途径的炎症。
- CAVAE 在调节 PI3K/AKT 和 Wnt-3a/β-连环蛋白 途径方面显示出缓解糖尿病性骨质疏松的潜力。
- γ射线与柑橘属 Aurantium 薰衣草油或纳米乳液联合使用显著增加了储藏谷物昆虫的死亡率，而不损害种子发芽。
Frequently asked questions
What is Bitter orange?
Bitter orange (Citrus × aurantium) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Bitter orange?
4 sourced findings are recorded for Bitter orange; the strongest carries evidence grade D. For example: 研究发现柑橘属Citrus aurantium果实精油中存在几种化合物，其对NF-κB和p38 MAPK的抑制潜力与标准抑制剂相当。
How strong is the evidence for Bitter orange?
The strongest finding for Bitter orange carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Bitter orange safe? What are the side effects?
No major safety issues are recorded for Bitter orange in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Bitter orange interact with medications?
No drug interactions are recorded for Bitter orange in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Bitter orange?
Bitter orange is also known as: Померанец, Bigaradier.
Is Bitter orange a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Composition analysis, QSAR, molecular docking, molecular dynamics simulation and ADMET profiles of Citrus aurantium fruit essential oil compounds as inhibitors of NF-κB and MAPK in brain injury. literature abstract metadata
- T2 Radiation-induced in vivo biochemical disruptions, acetylcholinesterase inhibition and synergistic radiosensitivity of 60Co-γ radiation integrated with Citrus aurantium nanoemulsions against Sitophilus oryzae (L.) and Tribolium castaneum (H literature abstract metadata
- T2 Integration of network pharmacology, deep learning, and molecular biology reveals the efficacy of Citrus aurantium L. var. amara Engl. blossom extract in ameliorating diabetic osteoporosis. literature abstract metadata
- T2 Citrus aurantium honey-mediated gut homeostasis and anti-inflammation via Thorl/Nprl2-TORC1 signaling: Network pharmacology and Drosophila validation. literature abstract metadata