Adlay
Coix lacryma-jobi
Coix lacryma-jobi，常被称为Job's Tears或coix种子，是一种传统上用于东亚医学的植物。它已被用于多种用途，例如治疗消化问题和促进整体健康，但具体的传统用途尚未得到充分记录。科学证据表明，将Coix lacryma-jobi与托瑞帕利玛（toripalimab）及化疗联合使用，在晚期非小细胞肺癌患者中显示出可控安全性和初步抗肿瘤活性，尽管这些发现仍需进一步验证。该植物的提取物coixol已证明具有抑制破骨细胞分化与骨吸收的潜力，通过激活HIF‑1α并抑制NF‑κB信号通路实现。此外，已建立TRV‑VIGS系统，用于利用Coix lacryma-jobi研究宿主-病原体相互作用，并通过甲基乙二醛（methylglyoxal）提升基因沉默效率。在安全性方面，没有记录到主要问题，目前也未报告与该植物相关的药物相互作用。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 康莱特注射液与托里帕利单抗和化疗联合使用在晚期NSCLC患者中显示出了可管理的安全性和初步的抗肿瘤活性，但这些发现仍需验证。
- 科希老抑制了体内外的成骨细胞分化和骨吸收，通过激活HIF-1α并抑制NF-κB信号传导。
- 该研究建立了一个TRV-VIGS系统来研究高粱中的宿主-病原体相互作用，并通过甲基乙二醛提高了基因沉默效率。
- Coix lacryma-jobi 种子在铵盐/硝酸盐比例为50/50时表现出最佳的碳积累，极端比例下效率降低。
- 研究发现，粟米种子粉增加了Taiwanofungus gaoligongensis中的萜烯类和黄酮类物质的积累，尤其是倍半萜烃和异黄酮。
Frequently asked questions
What is Adlay?
Adlay (Coix lacryma-jobi) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Adlay?
5 sourced findings are recorded for Adlay; the strongest carries evidence grade D. For example: 康莱特注射液与托里帕利单抗和化疗联合使用在晚期NSCLC患者中显示出了可管理的安全性和初步的抗肿瘤活性，但这些发现仍需验证。
How strong is the evidence for Adlay?
The strongest finding for Adlay carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Adlay safe? What are the side effects?
No major safety issues are recorded for Adlay in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Adlay interact with medications?
No drug interactions are recorded for Adlay in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Adlay?
Adlay is also known as: Иовлевы слёзы, Coix larme-de-Job, Larme-de-Job, Herbe à chapelets.
Is Adlay a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Coixol attenuates osteoclastogenesis and ovariectomy-induced bone loss via the HIF-1α-mediated suppression of NF-κB signaling. literature abstract metadata
- T2 Multi-omics analysis Taiwanofungus gaoligongensis fermentation with traditional Chinese medicine. literature abstract metadata
- T2 Elucidation of inorganic nitrogen utilization characteristics in Coix lacryma-jobi L. seedlings under variable ammonium/nitrate ratios via the 15N tracer technique. literature abstract metadata
- T2 Establishment of a TRV-VIGS system in Coix (Coix lacryma-jobi L.) for functional study of host-pathogen interactions. literature abstract metadata
- T2 Safety and Clinical Outcomes of Kanglaite Injection in Combination with Toripalimab and Chemotherapy for Advanced Non-Small Cell Lung Cancer: A Real-World Retrospective Analysis. literature abstract metadata