Hypericum
Hypericum
Hypericum is a genus of plants traditionally used in various herbal practices. Hypericum perforatum L., commonly known as St. John's Wort, has been studied for its potential antidepressant effects and is used in some traditional medicine systems to address depressive symptoms. Scientific evidence suggests that both H. perforatum and Chaihu Shugan San may alleviate depressive-like behaviors through different mechanisms but with overlapping pathways. Additionally, research indicates that H. perforatum and Glycyrrhiza glabra can preserve cardiac mitochondrial redox homeostasis in estrogen deficiency by modulating MAO-A and ERβ activity, while H. perforatum and Achillea millefolium essential oils show synergistic antibacterial effects against Staphylococcus epidermidis in specific oil combinations. Hypericum extracts also demonstrated significant sleep-promoting effects in mice, possibly through adenosine and melatonin receptor signaling. No major safety concerns or drug interactions have been recorded for Hypericum use to date.
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- BothHypericum perforatum L.（圣约翰草）和柴胡疏肝散通过不同的但部分重叠的分子机制缓解了抑郁样行为。
- Hypericum perforatum 和 Glycyrrhiza glabra 在雌激素缺乏时通过调节MAO-A和ERβ来维持心脏线粒体氧化还原稳态。
- Hypericum perforatum 和 Achillea millefolium 的精油在特定油组合中对 Staphylococcus epidermidis 显示出协同活性。
- HME 显著缩短了小鼠的入睡潜伏期并延长了总睡眠时间，表明其作用可能是通过腺苷和褪黑素受体信号传导介导的。
- Hypericum triquetrifolium 水醇提取物显示出强大的抗氧化和抗炎活性，并对胰腺癌细胞具有选择性细胞毒性。
Frequently asked questions
What is Hypericum?
Hypericum (Hypericum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Hypericum?
5 sourced findings are recorded for Hypericum; the strongest carries evidence grade D. For example: BothHypericum perforatum L.（圣约翰草）和柴胡疏肝散通过不同的但部分重叠的分子机制缓解了抑郁样行为。
How strong is the evidence for Hypericum?
The strongest finding for Hypericum carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Hypericum safe? What are the side effects?
No major safety issues are recorded for Hypericum in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Hypericum interact with medications?
No drug interactions are recorded for Hypericum in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Hypericum?
Hypericum is also known as: Зверобой, millepertuis.
Is Hypericum a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Chemical Composition and Synergistic Antimicrobial Activity of Hypericum perforatum and Achillea millefolium Essential Oils Against Wound-Associated Microorganisms. literature abstract metadata
- T2 In Vitro Evidence for the Dual Antioxidant and Anti-Inflammatory Roles of Hypericum triquetrifolium in Cancer Therapy: Selective Cytotoxicity Against Pancreatic Cancer Cells. literature abstract metadata
- T2 Hypericum perforatum L. and Glycyrrhiza glabra L. preserve cardiac mitochondrial redox homeostasis in E2 deficiency via ERβ-MAO-A modulation. literature abstract metadata
- T2 Integrative Proteomics Reveals Distinct Lipid Metabolic and Gut Microbiota-Associated Antidepressant Mechanisms of Two Herbal Medicines in a Chronic Stress Model. literature abstract metadata
- T2 Hypnotic Effects of Hypericum perforatum L. and Melissa officinalis L. Through Adenosine and Melatonin Receptors. literature abstract metadata