St. John's wort

Hypericum perforatum, commonly known as St. John's wort, is a traditional medicinal plant used in various European and folk medicine practices for treating mild depressive episodes and low mood. It has also been traditionally applied topically to manage minor wounds and burns. Scientific evidence suggests that Hypericum perforatum may have some benefits, particularly in reducing oral bacteria associated with dental plaque and gingivitis. Studies indicate synergistic activity against certain bacteria when combined with other essential oils. Additionally, research shows potential for improving sleep quality through adenosine and melatonin receptor signaling, though specific dosages are not well-documented. Safety concerns include photosensitivity, where the skin becomes more sensitive to sunlight, necessitating caution in sun exposure. Hypericum perforatum can interact with several medications; it may reduce the effectiveness of warfarin by inducing CYP3A4 and P-glycoprotein enzymes, potentially lowering drug blood levels and efficacy. It also interacts with oral contraceptives, possibly reducing their contraceptive effect due to enzyme induction. Furthermore, combining Hypericum perforatum with selective serotonin reuptake inhibitors (SSRIs) could lead to an increased risk of serotonin syndrome due to additive serotonergic effects.

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。