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Hypericum perforatum

Hypericum perforatum

Hypericum perforatum，常被称为圣约翰草，是一种传统植物，在多种欧洲和民间医学实践中用于治疗轻度抑郁发作和低落情绪。它也被传统地局部应用于处理小伤口和烧伤。科学证据表明，Hypericum perforatum提取物可能具有抗菌特性，可降低Streptococcus mutans数量并改善口腔健康参数，如牙菌斑指数和牙龈出血。此外，它通过与腺苷受体和褪黑激素受体的相互作用，在提升睡眠质量方面显示潜力，尽管具体机制尚未完全了解。在抑郁症方面，Hypericum perforatum以及其他传统疗法如柴胡疏肝散已在慢性压力条件下缓解类似抑郁行为方面表现出前景，但涉及的确切分子通路仍待阐明。 安全关注包括光敏感性，即皮肤对阳光更为敏感。药物相互作用也值得注意；它可诱导CYP3A4和P‑糖蛋白酶，可能降低华法林和口服避孕药的血液水平，从而降低其疗效。Hypericum perforatum还可能与SSRI抗抑郁剂相互作用，因其5-羟色胺能效应增加了5-羟色胺综合征的风险。

速览
传统用于
轻度抑郁发作/情绪低落 · 小伤口和烧伤（外用，传统）
传统体系
西方植物疗法
最佳证据
B
注意事项
⚕ 3 ⚠ 1

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。

传统用途

科学怎么说

  • 研究发现，Hypericum perforatum提取物牙龈显著减少了 Streptococcus mutans 数量、菌斑指数和牙龈出血，与未添加提取物的牙龈相比，尽管两种牙龈都增加了唾液 pH 值。 B PMID
  • HME 显著缩短了小鼠的入睡潜伏期并延长了总睡眠时间，表明其作用可能是通过腺苷和褪黑素受体信号传导介导的。 D PMID
  • Hypericum perforatum 和柴胡疏肝散在慢性应激模型中缓解了抑郁样行为，通过不同的分子机制涉及脂质代谢和更广泛的代谢过程。 D PMID
  • Hypericum perforatum 和 Glycyrrhiza glabra 治疗降低了 MAO-A 活性，恢复了 ERβ 表达并改善了雌激素缺乏条件下的线粒体功能，未明确给出剂量或建议。 D PMID
  • Hypericum perforatum 和 Achillea millefolium 的精油在特定油混合物中对 Staphylococcus epidermidis 显示出协同活性。 D PMID

安全性与毒性

  • 光敏性——皮肤对阳光更加敏感 moderate LIVERTOX

药物相互作用

  • 华法林 — 诱导CYP3A4 / P-糖蛋白 → 降低药物血浓度及其效果 A NCCIH
  • 口服避孕药 — 酶诱导 → 避孕效果降低，突破性出血 A NCCIH
  • 选择性血清素再摄取抑制剂 — 累加血清素效应 → 发生血清素综合征的风险 B NCCIH

Frequently asked questions

What is Hypericum perforatum?

Hypericum perforatum (Hypericum perforatum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What is Hypericum perforatum traditionally used for?

Traditional sources record Hypericum perforatum for: 轻度抑郁发作/情绪低落, 小伤口和烧伤（外用，传统）. This reflects traditional use, not a proven medical treatment.

Which traditions use Hypericum perforatum?

Hypericum perforatum appears in these traditions in our sources: Western phytotherapy.

What does the scientific evidence say about Hypericum perforatum?

5 sourced findings are recorded for Hypericum perforatum; the strongest carries evidence grade B. For example: 研究发现，Hypericum perforatum提取物牙龈显著减少了 Streptococcus mutans 数量、菌斑指数和牙龈出血，与未添加提取物的牙龈相比，尽管两种牙龈都增加了唾液 pH 值。

How strong is the evidence for Hypericum perforatum?

The strongest finding for Hypericum perforatum carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).

Is Hypericum perforatum safe? What are the side effects?

Reported effects associated with Hypericum perforatum include: 光敏性——皮肤对阳光更加敏感. This is informational only — consult a qualified professional before use.

Does Hypericum perforatum interact with medications?

Recorded drug interactions for Hypericum perforatum involve: 华法林, 口服避孕药, 选择性血清素再摄取抑制剂. Tell your doctor or pharmacist about any herb you take.

What are the common names of Hypericum perforatum?

Hypericum perforatum is also known as: Зверобой продырявленный.

Is Hypericum perforatum a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T1 EMA HMPC monograph: Hypericum perforatum (St. John's wort) © EU/EMA — reproduced with attribution
  2. T1 LiverTox: St. John's Wort public domain
  3. T2 NCCIH: St. John's Wort public domain (attribute NCCIH)
  4. T2 Clinical Assessment of the Effect of Hypericum perforatum Chewing Gum on Salivary Streptococcus mutans Count, pH, Plaque Index, and Gingival Bleeding: A Randomized Clinical Trial. literature abstract metadata
  5. T2 Chemical Composition and Synergistic Antimicrobial Activity of Hypericum perforatum and Achillea millefolium Essential Oils Against Wound-Associated Microorganisms. literature abstract metadata
  6. T2 Hypericum perforatum L. and Glycyrrhiza glabra L. preserve cardiac mitochondrial redox homeostasis in E2 deficiency via ERβ-MAO-A modulation. literature abstract metadata
  7. T2 Integrative Proteomics Reveals Distinct Lipid Metabolic and Gut Microbiota-Associated Antidepressant Mechanisms of Two Herbal Medicines in a Chronic Stress Model. literature abstract metadata
  8. T2 Hypnotic Effects of Hypericum perforatum L. and Melissa officinalis L. Through Adenosine and Melatonin Receptors. literature abstract metadata

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