Chardon-Marie
Silybum marianum · milk thistle
Silybum marianum, commonly known as milk thistle, is a traditional medicinal plant used in various cultures for centuries. It has been traditionally employed to support liver health and detoxification processes, although specific uses vary across different traditions. Scientific evidence suggests that silymarin, the active compound derived from Silybum marianum, may offer hepatoprotective effects by antagonizing liver X receptors. Additionally, there is promising in vitro and in vivo research indicating potential antineoplastic activity against prostate cancer, though more randomized trials are needed to confirm these findings. Notably, an enriched extract of Isosilybin A, when combined with fluconazole, has shown the ability to restore azole susceptibility in resistant Candida species. In contaminated fish studies, supplementation with sil (likely referring to silymarin) demonstrated some improvements in gene expression and immunity parameters compared to controls. No major safety issues or drug interactions have been recorded for Silybum marianum, though further research is ongoing to fully understand its potential benefits and applications.
- Meilleure preuve
- D
- Précautions
- —
Information uniquement. L'usage traditionnel ne signifie pas une efficacité prouvée. Les preuves et la sécurité varient — consultez les sources citées.
Ce que dit la science
- Le silymarine et ses flavonoïdes lignanes isolés antagonisent le récepteur X du foie, montrant des effets potentiellement antisteatothiques sur les cellules HepG2.
- Des composés dérivés de Silybum marianum montrent une activité antineoplastique prometteuse contre le cancer de la prostate chez les modèles in vitro et in vivo, mais des essais randomisés supplémentaires sont nécessaires.
- Extraits de Silybum marianum enrichi en iso-silibine A, associé au fluconazole, a restauré la sensibilité aux azoles chez les espèces de Candida résistantes aux azoles et les levures émergentes.
- La supplémentation en sialine a réduit les résidus d'afлатоксин и улучшил иммунные параметры у нильских тилапий, пораженных афлатоксиозом и бактериальной инфекцией.
Frequently asked questions
What is Chardon-Marie?
Chardon-Marie (Silybum marianum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Chardon-Marie?
4 sourced findings are recorded for Chardon-Marie; the strongest carries evidence grade D. For example: Le silymarine et ses flavonoïdes lignanes isolés antagonisent le récepteur X du foie, montrant des effets potentiellement antisteatothiques sur les cellules HepG2.
How strong is the evidence for Chardon-Marie?
The strongest finding for Chardon-Marie carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Chardon-Marie safe? What are the side effects?
No major safety issues are recorded for Chardon-Marie in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Chardon-Marie interact with medications?
No drug interactions are recorded for Chardon-Marie in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Chardon-Marie?
Chardon-Marie is also known as: milk thistle, расторопша.
Is Chardon-Marie a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Silybum marianum-Derived Compounds in Prostate Cancer: Mechanisms of Action and Translational Potential. literature abstract metadata
- T2 In silico identification of isosilybin a targeting squalene epoxidase as an antifungal adjuvant with in vitro validation against azole-resistant Candida and emerging yeasts. literature abstract metadata
- T2 Silymarin conserves the efficacy of quinolone and sulfonamide in Nile tilapia (Oreochromis niloticus) subjected to aflatoxicosis and Streptococcus agalactiae infection. literature abstract metadata
- T2 Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists. literature abstract metadata