Regel’s threewingnut
Tripterygium regelii
三叶鬼臼（Tripterygium regelii）原产于中国和日本，传统上未用于医疗用途。科学研究表明其具有针对 SARS-CoV 3CLpro 的潜在抗病毒活性，IC50 值为 2.6 ± 0.6 μmol L-1，并且通过激活 AHR 和抑制多种信号通路显示出有希望的抗炎作用。此外，其根部中的萜类化合物具有诱导对结直肠癌细胞的铁死亡的潜力。该植物在 A. nephrolepis 死亡后森林空地上的入侵模式表明生态互动，但没有记录直接医疗用途。目前未报告安全问题，并且没有证据显示有显著药物相互作用。
- 最佳证据
- A
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 从Tripterygium regelii树皮中提取的物质对SARS-CoV 3CLpro表现出强大的抑制活性，IC50为2.6±0.6μmol/L。
- 研究在Tripterygium regelii根中鉴定出了萜类化合物，其中一个新化合物通过诱导铁死亡显示出潜在的抗结肠直肠癌功效。
- 来自三叶鬼臼根的化合物7和13显示出显著的抗炎活性，通过激活AHR并抑制多个信号传导途径。
- 在林冠空隙中观察到Tripterygium regelii入侵，这可能阻碍树苗的再生。
Frequently asked questions
What is Regel’s threewingnut?
Regel’s threewingnut (Tripterygium regelii) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Regel’s threewingnut?
4 sourced findings are recorded for Regel’s threewingnut; the strongest carries evidence grade A. For example: 从Tripterygium regelii树皮中提取的物质对SARS-CoV 3CLpro表现出强大的抑制活性，IC50为2.6±0.6μmol/L。
How strong is the evidence for Regel’s threewingnut?
The strongest finding for Regel’s threewingnut carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Regel’s threewingnut safe? What are the side effects?
No major safety issues are recorded for Regel’s threewingnut in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Regel’s threewingnut interact with medications?
No drug interactions are recorded for Regel’s threewingnut in our sources. This does not rule them out — check with a pharmacist.
Is Regel’s threewingnut a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis. literature abstract metadata
- T2 Pre-drought effects on northern temperate trees and vine invasion in forest gaps hindering regeneration. literature abstract metadata
- T2 Macrolide sesquiterpene pyridine alkaloids from the roots of Tripterygium regelii and their anti-inflammatory activity. literature abstract metadata
- T2 Diterpenoids and triterpenoids from the roots of Tripterygium regelii and their inhibitory effects on colorectal cancer cells. literature abstract metadata