Regel’s threewingnut
Tripterygium regelii
Tripterygium regelii, a plant native to China and Japan, has not been traditionally used for medicinal purposes. Scientific research indicates potential anti-viral activity against SARS-CoV 3CLpro with an IC50 of 2.6 ± 0.6 μmol L-1, as well as promising anti-inflammatory effects through the activation of AHR and inhibition of several signaling pathways. Additionally, terpenoids from its roots have shown potential in inducing ferroptosis against colorectal cancer cells. The plant's invasion pattern after the death of A. nephrolepis in forest gaps suggests ecological interactions but no direct medicinal use has been recorded. Safety concerns are currently unreported, and there is no evidence of significant drug interactions noted.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Tripterygium regelii bark extracts showed potent activity against SARS-CoV 3CLpro with an IC50 of 2.6 ± 0.6 μmol L-1.
- The study identified terpenoids from Tripterygium regelii roots, with one new compound showing potential anti-colorectal cancer efficacy by inducing ferroptosis.
- Compounds 7 and 13 from Tripterygium regelii roots showed significant anti-inflammatory activity by activating AHR and inhibiting several signaling pathways.
- Tripterygium regelii invasion is observed after the death of A. nephrolepis in forest gaps, potentially hindering tree regeneration.
Frequently asked questions
What is Regel’s threewingnut?
Regel’s threewingnut (Tripterygium regelii) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Regel’s threewingnut?
4 sourced findings are recorded for Regel’s threewingnut; the strongest carries evidence grade A. For example: Tripterygium regelii bark extracts showed potent activity against SARS-CoV 3CLpro with an IC50 of 2.6 ± 0.6 μmol L-1.
How strong is the evidence for Regel’s threewingnut?
The strongest finding for Regel’s threewingnut carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Regel’s threewingnut safe? What are the side effects?
No major safety issues are recorded for Regel’s threewingnut in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Regel’s threewingnut interact with medications?
No drug interactions are recorded for Regel’s threewingnut in our sources. This does not rule them out — check with a pharmacist.
Is Regel’s threewingnut a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis. literature abstract metadata
- T2 Pre-drought effects on northern temperate trees and vine invasion in forest gaps hindering regeneration. literature abstract metadata
- T2 Macrolide sesquiterpene pyridine alkaloids from the roots of Tripterygium regelii and their anti-inflammatory activity. literature abstract metadata
- T2 Diterpenoids and triterpenoids from the roots of Tripterygium regelii and their inhibitory effects on colorectal cancer cells. literature abstract metadata