shiny-leaf prickly-ash
Zanthoxylum nitidum
Zanthoxylum nitidum 是一种传统上在东南亚发现的植物，尤其是在泰国和越南等国家。其传统用途尚未得到广泛记录，但根据最近的科学研究，它可能具有潜在的药用价值。研究已从 Zanthoxylum nitidum 中鉴定出 64 种化合物，其中包括 43 种生物碱，采用 UHPLC-Q-Exactive Orbitrap MS 等先进分析技术。氯化硝胺（Nitidine chloride）是其中一种已识别的化合物，它通过靶向 CENPE 展示了抗结直肠癌活性；然而，需要进一步验证以确认这些发现。另一种来自 Zanthoxylum nitidum 的化合物——血红素（Sanguinarine）可诱导肺鳞状细胞癌细胞的凋亡和铁死亡，靶向 BiP，并在体外和体内实验中得到支持。NC 已经证明具有抗炎和抗焦亡作用，通过抑制 NLRP3/Caspase-1/GSDMD 通路，在细胞和动物模型中表现出效果。尚未发现 Zanthoxylum nitidum 存在重大安全问题或已记录的药物相互作用，但仍需进一步研究以充分了解其潜在益处与风险。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 从乌药中使用UHPLC-Q-Exactive Orbitrap MS鉴定出64种化合物，其中包括43种生物碱。
- 来自Zanthoxylum nitidum的硝定氯表现出针对CENPE的抗结肠癌活性，尽管这些发现需要进一步验证。
- 血根碱通过靶向BiP在体外和体内实验中诱导肺鳞状细胞癌细胞的凋亡和铁死亡。
- NC 展现了抗炎和抗焦亡作用，通过抑制 NLRP3/Caspase-1/GSDMD 路径在细胞和动物模型中。
Frequently asked questions
What is shiny-leaf prickly-ash?
shiny-leaf prickly-ash (Zanthoxylum nitidum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about shiny-leaf prickly-ash?
4 sourced findings are recorded for shiny-leaf prickly-ash; the strongest carries evidence grade D. For example: 从乌药中使用UHPLC-Q-Exactive Orbitrap MS鉴定出64种化合物，其中包括43种生物碱。
How strong is the evidence for shiny-leaf prickly-ash?
The strongest finding for shiny-leaf prickly-ash carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is shiny-leaf prickly-ash safe? What are the side effects?
No major safety issues are recorded for shiny-leaf prickly-ash in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does shiny-leaf prickly-ash interact with medications?
No drug interactions are recorded for shiny-leaf prickly-ash in our sources. This does not rule them out — check with a pharmacist.
Is shiny-leaf prickly-ash a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Mechanistic Investigation of Nitidine Chloride-Mediated Anti-Colorectal Cancer Activity: Centromere-Associated Protein E Targeting via Integrated Molecular Dynamics, Spatial Transcriptomic and Single-Cell Approaches. literature abstract metadata
- T2 Nitidine chloride alleviates inflammation and pyroptosis by inhibiting the NLRP3/Caspase-1/GSDMD signaling pathway in macrophages and murine models. literature abstract metadata
- T2 Rapid Identification of Chemical Constituents of Zanthoxylum nitidum (Roxb.) DC. by Ultra-High-Performance Liquid Chromatography Quadrupole-Exactive Orbitrap Mass Spectrometry. literature abstract metadata
- T2 Sanguinarine triggers apoptosis and ferroptosis synchronously by directly binding BiP in lung squamous cell carcinoma. literature abstract metadata