shiny-leaf prickly-ash
Zanthoxylum nitidum
Zanthoxylum nitidum，这种植物原产于非洲热带地区，在传统医学中的应用尚未广泛记录。科学研究已通过先进的分析技术如UHPLC-Q-Exactive Orbitrap MS从该植物中鉴定出64种化合物，包括43种生物碱。其中一种鉴定出的成分血根碱在体外和体内实验中均显示出诱导肺鳞状细胞癌细胞凋亡和铁死亡的潜力，通过靶向BiP实现。此外，Zanthoxylum nitidum中的硝定氯化物表现出对结直肠癌的抑制作用，通过靶向CENPE；然而，需要进一步验证以确认这些发现。该植物还表现出抗炎和抗焦亡效应，通过抑制NLRP3/Caspase-1/GSDMD途径在细胞和动物模型中均有所体现。尚未记录Zanthoxylum nitidum的重大安全问题或已知药物相互作用，但需要进一步研究以全面了解其潜在应用及其副作用。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- 从乌药中使用UHPLC-Q-Exactive Orbitrap MS鉴定出64种化合物，其中包括43种生物碱。
- 来自Zanthoxylum nitidum的硝定氯表现出针对CENPE的抗结肠癌活性，尽管这些发现需要进一步验证。
- 血根碱通过靶向BiP在体外和体内实验中诱导肺鳞状细胞癌细胞的凋亡和铁死亡。
- NC 展现了抗炎和抗焦亡作用，通过抑制 NLRP3/Caspase-1/GSDMD 路径在细胞和动物模型中。
Frequently asked questions
What is shiny-leaf prickly-ash?
shiny-leaf prickly-ash (Zanthoxylum nitidum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about shiny-leaf prickly-ash?
4 sourced findings are recorded for shiny-leaf prickly-ash; the strongest carries evidence grade D. For example: 从乌药中使用UHPLC-Q-Exactive Orbitrap MS鉴定出64种化合物，其中包括43种生物碱。
How strong is the evidence for shiny-leaf prickly-ash?
The strongest finding for shiny-leaf prickly-ash carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is shiny-leaf prickly-ash safe? What are the side effects?
No major safety issues are recorded for shiny-leaf prickly-ash in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does shiny-leaf prickly-ash interact with medications?
No drug interactions are recorded for shiny-leaf prickly-ash in our sources. This does not rule them out — check with a pharmacist.
Is shiny-leaf prickly-ash a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Mechanistic Investigation of Nitidine Chloride-Mediated Anti-Colorectal Cancer Activity: Centromere-Associated Protein E Targeting via Integrated Molecular Dynamics, Spatial Transcriptomic and Single-Cell Approaches. literature abstract metadata
- T2 Nitidine chloride alleviates inflammation and pyroptosis by inhibiting the NLRP3/Caspase-1/GSDMD signaling pathway in macrophages and murine models. literature abstract metadata
- T2 Rapid Identification of Chemical Constituents of Zanthoxylum nitidum (Roxb.) DC. by Ultra-High-Performance Liquid Chromatography Quadrupole-Exactive Orbitrap Mass Spectrometry. literature abstract metadata
- T2 Sanguinarine triggers apoptosis and ferroptosis synchronously by directly binding BiP in lung squamous cell carcinoma. literature abstract metadata