shiny-leaf prickly-ash
Zanthoxylum nitidum
Zanthoxylum nitidum, a plant native to tropical regions of Africa, has not been extensively documented for traditional medicinal uses. Scientific research has identified 64 compounds from this plant, including 43 alkaloids, using advanced analytical techniques such as UHPLC-Q-Exactive Orbitrap MS. Sanguinarine, one of the identified compounds, has shown potential in inducing apoptosis and ferroptosis in lung squamous cell carcinoma cells through targeting BiP, with supporting evidence from both in vitro and in vivo experiments. Additionally, nitidine chloride from Zanthoxylum nitidum demonstrated anti-colorectal cancer activity by targeting CENPE; however, further validation is required to confirm these findings. The plant also exhibited anti-inflammatory and anti-pyroptotic effects by inhibiting the NLRP3/Caspase-1/GSDMD pathway in both cellular and animal models. No major safety concerns or known drug interactions have been recorded for Zanthoxylum nitidum, though further research is necessary to fully understand its potential applications and side effects.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- A total of 64 compounds, including 43 alkaloids, were identified from Zanthoxylum nitidum using UHPLC-Q-Exactive Orbitrap MS.
- Nitidine chloride from Zanthoxylum nitidum shows anti-colorectal cancer activity by targeting CENPE, though findings need further validation.
- Sanguinarine induces both apoptosis and ferroptosis in lung squamous cell carcinoma cells by targeting BiP, with supporting evidence from in vitro and in vivo experiments.
- NC exhibited anti-inflammatory and anti-pyroptotic effects by inhibiting the NLRP3/Caspase-1/GSDMD pathway in both cellular and animal models.
Frequently asked questions
What is shiny-leaf prickly-ash?
shiny-leaf prickly-ash (Zanthoxylum nitidum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about shiny-leaf prickly-ash?
4 sourced findings are recorded for shiny-leaf prickly-ash; the strongest carries evidence grade D. For example: A total of 64 compounds, including 43 alkaloids, were identified from Zanthoxylum nitidum using UHPLC-Q-Exactive Orbitrap MS.
How strong is the evidence for shiny-leaf prickly-ash?
The strongest finding for shiny-leaf prickly-ash carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is shiny-leaf prickly-ash safe? What are the side effects?
No major safety issues are recorded for shiny-leaf prickly-ash in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does shiny-leaf prickly-ash interact with medications?
No drug interactions are recorded for shiny-leaf prickly-ash in our sources. This does not rule them out — check with a pharmacist.
Is shiny-leaf prickly-ash a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Mechanistic Investigation of Nitidine Chloride-Mediated Anti-Colorectal Cancer Activity: Centromere-Associated Protein E Targeting via Integrated Molecular Dynamics, Spatial Transcriptomic and Single-Cell Approaches. literature abstract metadata
- T2 Nitidine chloride alleviates inflammation and pyroptosis by inhibiting the NLRP3/Caspase-1/GSDMD signaling pathway in macrophages and murine models. literature abstract metadata
- T2 Rapid Identification of Chemical Constituents of Zanthoxylum nitidum (Roxb.) DC. by Ultra-High-Performance Liquid Chromatography Quadrupole-Exactive Orbitrap Mass Spectrometry. literature abstract metadata
- T2 Sanguinarine triggers apoptosis and ferroptosis synchronously by directly binding BiP in lung squamous cell carcinoma. literature abstract metadata