Celandine
Chelidonium majus
Chelidonium majus, commonly known as greater celandine, originates from traditional medicine practices in Europe and Asia. It has been traditionally used for various conditions including liver disorders, skin diseases, and pain relief, though specific uses vary among different cultures. Scientific evidence suggests potential polypharmacological wound-healing activity through metabolites of C. majus, which have shown promise in promoting collagen expression in fibroblasts. Additionally, research indicates that Chelidonium majus root extract-loaded silk fibroin-chitosan nanoparticles may enhance wound healing, surpassing TGF-β-treated controls. The draft genomes of Bacillus and Pseudomonas strains from C. majus offer insights into plant growth promotion and protection, while hydro-alcoholic extracts have shown promising effects in surgical wounds compared to Valeriana officinalis, though more research is required for broader validation. No major safety issues or drug interactions have been recorded, but caution should be exercised due to the presence of toxic alkaloids such as chelerythrine.
- أفضل دليل
- D
- تحذيرات
- —
للمعلومات فقط. الاستخدام التقليدي لا يعني فعاليّة مثبتة. تختلف الأدلة والسلامة — راجع المصادر المذكورة.
ما يقوله العلم
- المركبات المetabolites لـ C. majus أظهرت نشاطًا محتملًا متعدد الأدوية في علاج الجروح في الظروف المختبرية، مما يدعم استخدامها في أنظمة مبنية على السيرسين.
- الاستخراج من جذر تشيليدونيوم ماجوس المحمول في نانوrvineات الصوف البري والكوتوزان أدى إلى زيادة تعبير الكولاجين I و III في الأفيوبلاست، مما تجاوز التحكمات المعالجة بـ TGF-β.
- تم تقارير سequences الجينوم التمهيدي للاسортمنتات من جنس Bacillus و Pseudomonas من Chelidonium majus و Cannabis sativa، مما يوفر أساسًا للتحليلات الوظيفية المستقبلية.
- وجدت الدراسة أن السحب الهيدروالكحولي من Chelidonium majus و Valeriana officinalis أظهرت نسب شفاء جروح موعودة في الفئران، مع كون Chelidonium majus أكثر فعالية.
Frequently asked questions
What is Celandine?
Celandine (Chelidonium majus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Celandine?
4 sourced findings are recorded for Celandine; the strongest carries evidence grade D. For example: المركبات المetabolites لـ C. majus أظهرت نشاطًا محتملًا متعدد الأدوية في علاج الجروح في الظروف المختبرية، مما يدعم استخدامها في أنظمة مبنية على السيرسين.
How strong is the evidence for Celandine?
The strongest finding for Celandine carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Celandine safe? What are the side effects?
No major safety issues are recorded for Celandine in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Celandine interact with medications?
No drug interactions are recorded for Celandine in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Celandine?
Celandine is also known as: Чистотел большой, Chelidoine.
Is Celandine a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
المصادر
- T2 Wound Healing Traits of Chelidonium Majus and Valeriana Officinalis Hydro-Alcoholic Extracts on Surgical Wounds in Wistar Rats. literature abstract metadata
- T2 Molecular and Pharmacokinetic Rationale for the Use of Chelidonium majus L. in Wound Healing: An In Silico and In Vitro Validation. literature abstract metadata
- T2 Draft genome sequences of Bacillus and Pseudomonas species isolated from Cannabis sativa L. and Chelidonium majus L. literature abstract metadata
- T2 Phytochemical-loaded silk fibroin-chitosan nanocarriers for modulating collagen I/III expression via controlled bioorganic interactions. literature abstract metadata