Celandine

Chelidonium majus

Chelidonium majus, commonly known as greater celandine, originates from traditional medicine practices in Europe and Asia. It has been traditionally used for various conditions including liver disorders, skin diseases, and pain relief, though specific uses vary among different cultures. Scientific evidence suggests potential polypharmacological wound-healing activity through metabolites of C. majus, which have shown promise in promoting collagen expression in fibroblasts. Additionally, research indicates that Chelidonium majus root extract-loaded silk fibroin-chitosan nanoparticles may enhance wound healing, surpassing TGF-β-treated controls. The draft genomes of Bacillus and Pseudomonas strains from C. majus offer insights into plant growth promotion and protection, while hydro-alcoholic extracts have shown promising effects in surgical wounds compared to Valeriana officinalis, though more research is required for broader validation. No major safety issues or drug interactions have been recorded, but caution should be exercised due to the presence of toxic alkaloids such as chelerythrine.

速览
最佳证据
D
注意事项

仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同,请查阅所引来源。

科学怎么说

  • C. majus 的代谢物在体外显示出潜在的多药理学伤口愈合活性,支持其用于丝素基系统。 D PMID
  • 用丝素蛋白和壳聚糖纳米颗粒装载的金缕梅根提取物促进了成纤维细胞中I型和III型胶原蛋白的表达,超过了TGF-β处理的对照组。 D PMID
  • 报告了来自Chelidonium majus和Cannabis sativa的Bacillus和Pseudomonas物种的草图基因组序列,为将来的功能分析提供了基础。 D PMID
  • 研究发现,从大黄花属植物和瓦勒瑞纳官方植物中提取的水醇提取物在小鼠伤口愈合方面表现出有希望的速度,并且大黄花属植物更为有效。 D PMID

Frequently asked questions

What is Celandine?

Celandine (Chelidonium majus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Celandine?

4 sourced findings are recorded for Celandine; the strongest carries evidence grade D. For example: C. majus 的代谢物在体外显示出潜在的多药理学伤口愈合活性,支持其用于丝素基系统。

How strong is the evidence for Celandine?

The strongest finding for Celandine carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Celandine safe? What are the side effects?

No major safety issues are recorded for Celandine in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Celandine interact with medications?

No drug interactions are recorded for Celandine in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Celandine?

Celandine is also known as: Чистотел большой, Chelidoine.

Is Celandine a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

来源

  1. T2 Wound Healing Traits of Chelidonium Majus and Valeriana Officinalis Hydro-Alcoholic Extracts on Surgical Wounds in Wistar Rats. literature abstract metadata
  2. T2 Molecular and Pharmacokinetic Rationale for the Use of Chelidonium majus L. in Wound Healing: An In Silico and In Vitro Validation. literature abstract metadata
  3. T2 Draft genome sequences of Bacillus and Pseudomonas species isolated from Cannabis sativa L. and Chelidonium majus L. literature abstract metadata
  4. T2 Phytochemical-loaded silk fibroin-chitosan nanocarriers for modulating collagen I/III expression via controlled bioorganic interactions. literature abstract metadata