Celandine
Chelidonium majus
Chelidonium majus, commonly known as greater celandine, originates from traditional medicine practices in Europe and Asia. It has been traditionally used for various conditions including liver disorders, skin diseases, and pain relief, though specific uses vary among different cultures. Scientific evidence suggests potential polypharmacological wound-healing activity through metabolites of C. majus, which have shown promise in promoting collagen expression in fibroblasts. Additionally, research indicates that Chelidonium majus root extract-loaded silk fibroin-chitosan nanoparticles may enhance wound healing, surpassing TGF-β-treated controls. The draft genomes of Bacillus and Pseudomonas strains from C. majus offer insights into plant growth promotion and protection, while hydro-alcoholic extracts have shown promising effects in surgical wounds compared to Valeriana officinalis, though more research is required for broader validation. No major safety issues or drug interactions have been recorded, but caution should be exercised due to the presence of toxic alkaloids such as chelerythrine.
- Beste Evidenz
- D
- Warnhinweise
- —
Nur zur Information. Traditionelle Anwendung bedeutet keine nachgewiesene Wirksamkeit. Evidenz und Sicherheit variieren — siehe die angegebenen Quellen.
Was die Wissenschaft sagt
- Die Metaboliten von C. majus zeigten eine potentielle polyfarmakologische Wundheilungsaktivität in vitro an, was ihre Nutzung in Serinsystemen unterstützt.
- extrakt der Wurzel von Chelidonium majus in silberfaden-Chitosan-Nanopartikeln vergrößerte die Collagin I und III-Ausdrucksrate bei Fibroblasten, übertraf die Kontrollversuche mit TGF-β.
- Draft-Genomschläge von Bakterienarten der Gattungen Bacillus und Pseudomonas aus Chelidonium majus und Cannabis sativa wurden berichtet, was eine Grundlage für zukünftige funktionalanalytische Arbeiten bildet.
- Die Studie zeigte, dass hydroalkoholische Extrakte aus Chelidonium majus und Valeriana officinalis verheilungsfördernde Wirkungen bei Ratten aufwiesen, wobei Chelidonium majus die effektiver war.
Frequently asked questions
What is Celandine?
Celandine (Chelidonium majus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Celandine?
4 sourced findings are recorded for Celandine; the strongest carries evidence grade D. For example: Die Metaboliten von C. majus zeigten eine potentielle polyfarmakologische Wundheilungsaktivität in vitro an, was ihre Nutzung in Serinsystemen unterstützt.
How strong is the evidence for Celandine?
The strongest finding for Celandine carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Celandine safe? What are the side effects?
No major safety issues are recorded for Celandine in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Celandine interact with medications?
No drug interactions are recorded for Celandine in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Celandine?
Celandine is also known as: Чистотел большой, Chelidoine.
Is Celandine a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Quellen
- T2 Wound Healing Traits of Chelidonium Majus and Valeriana Officinalis Hydro-Alcoholic Extracts on Surgical Wounds in Wistar Rats. literature abstract metadata
- T2 Molecular and Pharmacokinetic Rationale for the Use of Chelidonium majus L. in Wound Healing: An In Silico and In Vitro Validation. literature abstract metadata
- T2 Draft genome sequences of Bacillus and Pseudomonas species isolated from Cannabis sativa L. and Chelidonium majus L. literature abstract metadata
- T2 Phytochemical-loaded silk fibroin-chitosan nanocarriers for modulating collagen I/III expression via controlled bioorganic interactions. literature abstract metadata