Celandine
Chelidonium majus
Chelidonium majus, commonly known as greater celandine, originates from traditional medicine practices in Europe and Asia. It has been traditionally used for various conditions including liver disorders, skin diseases, and pain relief, though specific uses vary among different cultures. Scientific evidence suggests potential polypharmacological wound-healing activity through metabolites of C. majus, which have shown promise in promoting collagen expression in fibroblasts. Additionally, research indicates that Chelidonium majus root extract-loaded silk fibroin-chitosan nanoparticles may enhance wound healing, surpassing TGF-β-treated controls. The draft genomes of Bacillus and Pseudomonas strains from C. majus offer insights into plant growth promotion and protection, while hydro-alcoholic extracts have shown promising effects in surgical wounds compared to Valeriana officinalis, though more research is required for broader validation. No major safety issues or drug interactions have been recorded, but caution should be exercised due to the presence of toxic alkaloids such as chelerythrine.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- C. majus metabolites showed potential polypharmacological wound-healing activity in vitro, supporting their use in sericin-based systems.
- Chelidonium majus root extract-loaded silk fibroin-chitosan nanoparticles promoted collagen I and III expression in fibroblasts, surpassing TGF-β-treated controls.
- Draft genome sequences of Bacillus and Pseudomonas species from Chelidonium majus and Cannabis sativa were reported, offering a basis for future functional analyses.
- The study found that hydro-alcoholic extracts from Chelidonium majus and Valeriana officinalis showed promising wound healing rates in rats, with C. majus being more effective.
Frequently asked questions
What is Celandine?
Celandine (Chelidonium majus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Celandine?
4 sourced findings are recorded for Celandine; the strongest carries evidence grade D. For example: C. majus metabolites showed potential polypharmacological wound-healing activity in vitro, supporting their use in sericin-based systems.
How strong is the evidence for Celandine?
The strongest finding for Celandine carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Celandine safe? What are the side effects?
No major safety issues are recorded for Celandine in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Celandine interact with medications?
No drug interactions are recorded for Celandine in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Celandine?
Celandine is also known as: Чистотел большой, Chelidoine.
Is Celandine a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Wound Healing Traits of Chelidonium Majus and Valeriana Officinalis Hydro-Alcoholic Extracts on Surgical Wounds in Wistar Rats. literature abstract metadata
- T2 Molecular and Pharmacokinetic Rationale for the Use of Chelidonium majus L. in Wound Healing: An In Silico and In Vitro Validation. literature abstract metadata
- T2 Draft genome sequences of Bacillus and Pseudomonas species isolated from Cannabis sativa L. and Chelidonium majus L. literature abstract metadata
- T2 Phytochemical-loaded silk fibroin-chitosan nanocarriers for modulating collagen I/III expression via controlled bioorganic interactions. literature abstract metadata