FolkKB

St. John's wort

Hypericum perforatum

Hypericum perforatum, commonly known as St. John's wort, is a traditional medicinal plant used in various European and folk medicine practices for treating mild depressive episodes and low mood. It has also been traditionally applied topically to manage minor wounds and burns. Scientific evidence suggests that Hypericum perforatum may have some benefits, particularly in reducing oral bacteria associated with dental plaque and gingivitis. Studies indicate synergistic activity against certain bacteria when combined with other essential oils. Additionally, research shows potential for improving sleep quality through adenosine and melatonin receptor signaling, though specific dosages are not well-documented. Safety concerns include photosensitivity, where the skin becomes more sensitive to sunlight, necessitating caution in sun exposure. Hypericum perforatum can interact with several medications; it may reduce the effectiveness of warfarin by inducing CYP3A4 and P-glycoprotein enzymes, potentially lowering drug blood levels and efficacy. It also interacts with oral contraceptives, possibly reducing their contraceptive effect due to enzyme induction. Furthermore, combining Hypericum perforatum with selective serotonin reuptake inhibitors (SSRIs) could lead to an increased risk of serotonin syndrome due to additive serotonergic effects.

لمحة سريعة
يُستخدَم تقليديًا لـ
períodos اكتئاب خفيف / مزاج منخفض · الجروح الخفيفة والحرائق (محلي، تقليدي)
التقاليد
العلاج النباتي الغربي
أفضل دليل
B
تحذيرات
⚕ 3 ⚠ 1

للمعلومات فقط. الاستخدام التقليدي لا يعني فعاليّة مثبتة. تختلف الأدلة والسلامة — راجع المصادر المذكورة.

الاستخدام التقليدي

ما يقوله العلم

  • وجدت الدراسة أن سحب Hypericum perforatum يقلل بشكل كبير من عدد Streptococcus mutans ومؤشر الترسب وأعراض النزيف اللثوي مقارنة باللثة بدون السحب، على الرغم من زيادة حموضة اللعاب في كلا الحالتين. B PMID
  • HME显著缩短了小鼠的入睡潜伏期并延长了总睡眠时间，表明其作用可能是通过腺苷和褪黑素受体信号传导介导的。 D PMID
  • كلاً من Hypericum perforatum و Chaihu Shugan San أخفى سلوكيات الاكتئاب في نموذج التوتر المزمن، مع أنماط ميكانيزمية مختلفة تشمل عملية الأحماض الدهنية والعمليات新陈代谢相关词汇： D PMID
  • العلاجات بـ Hypericum perforatum و Glycyrrhiza glabra خفضت نشاط MAO-A، استعادت التعبير عن ERβ وأمَّنت وظيفة الميتوكوندريا في ظروف نقص الإستروجين دون تحديد جرعة أو توصية صريحة. D PMID
  • زيوت البارفان من Hypericum perforatum و Achillea millefolium أظهرت نشاطًا سينergic ضد Staphylococcus epidermidis في مixtures معينة من الزيت. D PMID

السلامة والسُّمّية

  • حساسية الضوء — الجلد يصبح أكثر حساسية للضوء الشمسي moderate LIVERTOX

التفاعلات الدوائية

  • وارفارين — induces CYP3A4 / P-glycoprotein → lowers drug blood levels and effect A NCCIH
  • موانع حمل فموية — التحفيز الاميني → تقليل فعالية وسائل контрацепция، نزيف خارج الدورة الشهرية A NCCIH
  • مضادات الاكتئاب SSRI — التأثير السروتونيني الإضافي → خطر اضطراب السروتونين B NCCIH

Frequently asked questions

What is St. John's wort?

St. John's wort (Hypericum perforatum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What is St. John's wort traditionally used for?

Traditional sources record St. John's wort for: períodos اكتئاب خفيف / مزاج منخفض, الجروح الخفيفة والحرائق (محلي، تقليدي). This reflects traditional use, not a proven medical treatment.

Which traditions use St. John's wort?

St. John's wort appears in these traditions in our sources: Western phytotherapy.

What does the scientific evidence say about St. John's wort?

5 sourced findings are recorded for St. John's wort; the strongest carries evidence grade B. For example: وجدت الدراسة أن سحب Hypericum perforatum يقلل بشكل كبير من عدد Streptococcus mutans ومؤشر الترسب وأعراض النزيف اللثوي مقارنة باللثة بدون السحب، على الرغم من زيادة حموضة اللعاب في كلا الحالتين.

How strong is the evidence for St. John's wort?

The strongest finding for St. John's wort carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).

Is St. John's wort safe? What are the side effects?

Reported effects associated with St. John's wort include: حساسية الضوء — الجلد يصبح أكثر حساسية للضوء الشمسي. This is informational only — consult a qualified professional before use.

Does St. John's wort interact with medications?

Recorded drug interactions for St. John's wort involve: وارفارين, موانع حمل فموية, مضادات الاكتئاب SSRI. Tell your doctor or pharmacist about any herb you take.

What are the common names of St. John's wort?

St. John's wort is also known as: зверобой, Millepertuis.

Is St. John's wort a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

المصادر

  1. T1 EMA HMPC monograph: Hypericum perforatum (St. John's wort) © EU/EMA — reproduced with attribution
  2. T1 LiverTox: St. John's Wort public domain
  3. T2 NCCIH: St. John's Wort public domain (attribute NCCIH)
  4. T2 Clinical Assessment of the Effect of Hypericum perforatum Chewing Gum on Salivary Streptococcus mutans Count, pH, Plaque Index, and Gingival Bleeding: A Randomized Clinical Trial. literature abstract metadata
  5. T2 Chemical Composition and Synergistic Antimicrobial Activity of Hypericum perforatum and Achillea millefolium Essential Oils Against Wound-Associated Microorganisms. literature abstract metadata
  6. T2 Hypericum perforatum L. and Glycyrrhiza glabra L. preserve cardiac mitochondrial redox homeostasis in E2 deficiency via ERβ-MAO-A modulation. literature abstract metadata
  7. T2 Integrative Proteomics Reveals Distinct Lipid Metabolic and Gut Microbiota-Associated Antidepressant Mechanisms of Two Herbal Medicines in a Chronic Stress Model. literature abstract metadata
  8. T2 Hypnotic Effects of Hypericum perforatum L. and Melissa officinalis L. Through Adenosine and Melatonin Receptors. literature abstract metadata

مزيد من نباتات Hypericum