Millepertuis
Hypericum perforatum · St. John's wort
Hypericum perforatum, commonly known as St. John's wort, is a traditional medicinal plant used in various European and folk medicine practices for treating mild depressive episodes and low mood. It has also been traditionally applied topically to manage minor wounds and burns. Scientific evidence suggests that Hypericum perforatum may have some benefits, particularly in reducing oral bacteria associated with dental plaque and gingivitis. Studies indicate synergistic activity against certain bacteria when combined with other essential oils. Additionally, research shows potential for improving sleep quality through adenosine and melatonin receptor signaling, though specific dosages are not well-documented. Safety concerns include photosensitivity, where the skin becomes more sensitive to sunlight, necessitating caution in sun exposure. Hypericum perforatum can interact with several medications; it may reduce the effectiveness of warfarin by inducing CYP3A4 and P-glycoprotein enzymes, potentially lowering drug blood levels and efficacy. It also interacts with oral contraceptives, possibly reducing their contraceptive effect due to enzyme induction. Furthermore, combining Hypericum perforatum with selective serotonin reuptake inhibitors (SSRIs) could lead to an increased risk of serotonin syndrome due to additive serotonergic effects.
- Usage traditionnel
- épisodes dépressifs légers / mauvaise humeur · petites lésions et brûlures (topique, traditionnel)
- Traditions
- phytothérapie occidentale
- Meilleure preuve
- B
- Précautions
- ⚕ 3 ⚠ 1
Information uniquement. L'usage traditionnel ne signifie pas une efficacité prouvée. Les preuves et la sécurité varient — consultez les sources citées.
Usage traditionnel
Ce que dit la science
- L'étude a montré que l'extrait dHypericum perforatum sur les gencives a considérablement réduit le nombre de Streptococcus mutans, l'indice de plaque et le saignement gingival par rapport aux gencives sans l'extrait, bien que la salive des deux groupes ait augmenté l'acidité.
- L’HME a réduit significativement le délai d'endormissement et a prolongé le temps total de sommeil chez les souris, suggérant des effets modulés par la signification des récepteurs d'adénosine et de mélatonine.
- Hypericum perforatum et Chaihu Shugan San ont atténué les comportements dépressifs dans un modèle d’stress chronique, avec des mécanismes moléculaires distincts impliquant la métabolisme des lipides et des processus métaboliques plus larges.
- Les traitements avec Hypericum perforatum et Glycyrrhiza glabra ont réduit l'activité de MAO-A, restauré l'expression d'ERβ et amélioré la fonction mitochondriale dans les conditions de déficience en œstrogènes sans spécifier de dose ou recommandation explicite.
- Les huiles essentielles d'Hypericum perforatum et d'Achillea millefolium ont montré une activité synergétique contre Staphylococcus epidermidis dans certaines mélanges d'huile.
Sécurité et toxicité
- photosensibilité — la peau devient plus sensible à la lumière du soleil
Interactions médicamenteuses
- warfarine — induces CYP3A4 / P-glycoprotein → lowers drug blood levels and effect
- contraceptifs oraux — induction enzymatique → réduction de l'efficacité contraceptive, saignement entre les règles
- Antidépresseurs SSRI — effet sérotoninergique additif → risque de syndrome sérotoninique
Frequently asked questions
What is Millepertuis?
Millepertuis (Hypericum perforatum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What is Millepertuis traditionally used for?
Traditional sources record Millepertuis for: épisodes dépressifs légers / mauvaise humeur, petites lésions et brûlures (topique, traditionnel). This reflects traditional use, not a proven medical treatment.
Which traditions use Millepertuis?
Millepertuis appears in these traditions in our sources: Western phytotherapy.
What does the scientific evidence say about Millepertuis?
5 sourced findings are recorded for Millepertuis; the strongest carries evidence grade B. For example: L'étude a montré que l'extrait dHypericum perforatum sur les gencives a considérablement réduit le nombre de Streptococcus mutans, l'indice de plaque et le saignement gingival par rapport aux gencives sans l'extrait, bien que la salive des deux groupes ait augmenté l'acidité.
How strong is the evidence for Millepertuis?
The strongest finding for Millepertuis carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Millepertuis safe? What are the side effects?
Reported effects associated with Millepertuis include: photosensibilité — la peau devient plus sensible à la lumière du soleil. This is informational only — consult a qualified professional before use.
Does Millepertuis interact with medications?
Recorded drug interactions for Millepertuis involve: warfarine, contraceptifs oraux, Antidépresseurs SSRI. Tell your doctor or pharmacist about any herb you take.
What are the common names of Millepertuis?
Millepertuis is also known as: St. John's wort, зверобой.
Is Millepertuis a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T1 EMA HMPC monograph: Hypericum perforatum (St. John's wort) © EU/EMA — reproduced with attribution
- T1 LiverTox: St. John's Wort public domain
- T2 NCCIH: St. John's Wort public domain (attribute NCCIH)
- T2 Clinical Assessment of the Effect of Hypericum perforatum Chewing Gum on Salivary Streptococcus mutans Count, pH, Plaque Index, and Gingival Bleeding: A Randomized Clinical Trial. literature abstract metadata
- T2 Chemical Composition and Synergistic Antimicrobial Activity of Hypericum perforatum and Achillea millefolium Essential Oils Against Wound-Associated Microorganisms. literature abstract metadata
- T2 Hypericum perforatum L. and Glycyrrhiza glabra L. preserve cardiac mitochondrial redox homeostasis in E2 deficiency via ERβ-MAO-A modulation. literature abstract metadata
- T2 Integrative Proteomics Reveals Distinct Lipid Metabolic and Gut Microbiota-Associated Antidepressant Mechanisms of Two Herbal Medicines in a Chronic Stress Model. literature abstract metadata
- T2 Hypnotic Effects of Hypericum perforatum L. and Melissa officinalis L. Through Adenosine and Melatonin Receptors. literature abstract metadata