Cinchona Bark
Cinchona
Cinchona is a genus of trees native to South America. Its traditional use for treating malaria dates back centuries, particularly in indigenous Andean cultures. The bark contains quinine and other alkaloids that have been historically used against fevers and malaria. Scientific evidence supports the use of cinchona alkaloids in the treatment of malaria, although studies are limited and results vary. Research indicates potential applications in asymmetric organic synthesis, such as enantioselective addition reactions and cycloadditions, though these findings do not directly relate to traditional medicinal uses. No significant safety concerns or drug interactions have been reported for cinchona use in traditional medicine.
- Beste Evidenz
- D
- Warnhinweise
- —
Nur zur Information. Traditionelle Anwendung bedeutet keine nachgewiesene Wirksamkeit. Evidenz und Sicherheit variieren — siehe die angegebenen Quellen.
Was die Wissenschaft sagt
- This study reports a silver-catalyzed asymmetric [3+2] cycloaddition reaction that constructs C-N axial chirality and two stereocenters in oxazolines with high yields and selectivities.
- Tortis Arbeit betonte die therapeutische Verwendung der Quinquinaschale bei Malaria und trug zur Verbreitung in Europa bei.
- Diese Studie berichtet über die erfolgreiche enantioselective Addition von Thiolen an Pyrazolone-Ketiminen unter Verwendung von C-2' aminoorganokatalsytoren, die aus Cinchona-Alkaloiden abgeleitet wurden, was hohe Yields und Enantioselektivität erzielt.
- Beide peptidische und Cinchona-Katalysatoren wurden identifiziert, die die Hintergrundreaktivität bei der asymmetrischen Trifluoroacetlyation von Sulfondiaminen überbieten.
Frequently asked questions
What is Cinchona Bark?
Cinchona Bark (Cinchona) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Cinchona Bark?
4 sourced findings are recorded for Cinchona Bark; the strongest carries evidence grade D. For example: This study reports a silver-catalyzed asymmetric [3+2] cycloaddition reaction that constructs C-N axial chirality and two stereocenters in oxazolines with high yields and selectivities.
How strong is the evidence for Cinchona Bark?
The strongest finding for Cinchona Bark carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Cinchona Bark safe? What are the side effects?
No major safety issues are recorded for Cinchona Bark in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Cinchona Bark interact with medications?
No drug interactions are recorded for Cinchona Bark in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Cinchona Bark?
Cinchona Bark is also known as: Хинное дерево, Quinquina.
Is Cinchona Bark a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Quellen
- T2 Assessment of Complementary Catalysts in an Uncharted Enantioselective Reaction of Sulfondiimines. literature abstract metadata
- T2 Enantioselective Addition of Thiols to Pyrazolone Ketimines by Cinchona Alkaloid-Derived C-2' Amino Organocatalyst. literature abstract metadata
- T2 Silver-catalyzed asymmetric [3+2] cycloaddition via dynamic kinetic resolution: access to chiral oxazolines bearing C-N axial chirality. literature abstract metadata
- T2 Francesco Torti (1658-1741) and his description on the therapeutic use of quinine: the first effective method of treating malaria based on an extract of the bark of the Peruvian cinchona tree. literature abstract metadata