Cinchona Bark
Cinchona
Cinchona is a genus of trees native to South America. Its traditional use for treating malaria dates back centuries, particularly in indigenous Andean cultures. The bark contains quinine and other alkaloids that have been historically used against fevers and malaria. Scientific evidence supports the use of cinchona alkaloids in the treatment of malaria, although studies are limited and results vary. Research indicates potential applications in asymmetric organic synthesis, such as enantioselective addition reactions and cycloadditions, though these findings do not directly relate to traditional medicinal uses. No significant safety concerns or drug interactions have been reported for cinchona use in traditional medicine.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- This study reports a silver-catalyzed asymmetric [3+2] cycloaddition reaction that constructs C-N axial chirality and two stereocenters in oxazolines with high yields and selectivities.
- Torti's work highlighted the therapeutic use of cinchona bark for malaria treatment, contributing to its spread in Europe.
- This study reports the successful enantioselective addition of thiols to pyrazolone ketimines using cinchona alkaloid-derived C-2' amino organocatalysts, achieving high yields and enantioselectivity.
- Both peptidic and cinchona catalysts were identified that outcompete the background reactivity for the asymmetric trifluoroacetylation of sulfondiimines.
Frequently asked questions
What is Cinchona Bark?
Cinchona Bark (Cinchona) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Cinchona Bark?
4 sourced findings are recorded for Cinchona Bark; the strongest carries evidence grade D. For example: This study reports a silver-catalyzed asymmetric [3+2] cycloaddition reaction that constructs C-N axial chirality and two stereocenters in oxazolines with high yields and selectivities.
How strong is the evidence for Cinchona Bark?
The strongest finding for Cinchona Bark carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Cinchona Bark safe? What are the side effects?
No major safety issues are recorded for Cinchona Bark in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Cinchona Bark interact with medications?
No drug interactions are recorded for Cinchona Bark in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Cinchona Bark?
Cinchona Bark is also known as: Хинное дерево, Quinquina.
Is Cinchona Bark a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Assessment of Complementary Catalysts in an Uncharted Enantioselective Reaction of Sulfondiimines. literature abstract metadata
- T2 Enantioselective Addition of Thiols to Pyrazolone Ketimines by Cinchona Alkaloid-Derived C-2' Amino Organocatalyst. literature abstract metadata
- T2 Silver-catalyzed asymmetric [3+2] cycloaddition via dynamic kinetic resolution: access to chiral oxazolines bearing C-N axial chirality. literature abstract metadata
- T2 Francesco Torti (1658-1741) and his description on the therapeutic use of quinine: the first effective method of treating malaria based on an extract of the bark of the Peruvian cinchona tree. literature abstract metadata