FolkKB

Bine

Humulus lupulus

Humulus lupulus, commonly known as hops, is a traditional plant used primarily for brewing beer. While its use in traditional medicine has not been extensively documented, it has shown potential in various scientific studies. In adults with Crohn's disease, xanthohumol at 24 mg/day was well-tolerated and demonstrated minor beneficial trends regarding body mass index (BMI) and gamma-glutamyl transferase (GGT). Hops have also been explored as feed additives for different animal species, showing variable effects; while some benefits were observed, there were also dose-dependent adverse impacts. Genome-wide association studies (GWAS) did not identify significant single nucleotide polymorphisms (SNPs), but found several candidate loci, including a wall-associated kinase, associated with resistance to Verticillium wilt in hop plants. In a study using CCl₄-induced nephrotoxicity rats, Humulus lupulus extract significantly reduced serum urea and creatinine levels, decreased uric acid, and increased antioxidant activities such as TAC, CAT, SOD, and GPx. Safety concerns for Humulus lupulus are minimal based on current data. There have been no major issues recorded regarding its use. Similarly, there is currently no evidence of significant drug interactions associated with this plant.

Auf einen Blick
Beste Evidenz
B
Warnhinweise
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Nur zur Information. Traditionelle Anwendung bedeutet keine nachgewiesene Wirksamkeit. Evidenz und Sicherheit variieren — siehe die angegebenen Quellen.

Was die Wissenschaft sagt

  • Xanthohumol in einer Dosis von 24 mg pro Tag wurde gut vertragen und zeigte geringe vorteilhafte Trends im BMI und der GGT bei Erwachsenen mit Chronischer Darmerkrankung. B PMID
  • Hopfen zeigte variierende Wirkungen als Futtermittelzusatz in verschiedenen Tierarten, mit einigen Vorteilen aber auch dosisabhängigen negativen Auswirkungen. D PMID
  • GWAS konnte keine signifikanten SNPs identifizieren, aber es wurden mehrere kandidierte Loci, einschließlich einer Wand-Associated-Kinase, für die Widerstandsfähigkeit gegen das Verticillium-Wilts-Syndrom bei Hopfen ermittelt. D PMID
  • Das Humulus lupulus-Extrakt reduzierte die Serumurea-, Creatinin- und Uric-Säurewerte sowie die MDA-Werte im Nierenweichgewebe bei Ratten mit CCl₄-induzierter Nephrotoxizität, während die TAC-, CAT-, SOD- und GPx-Aktivitäten erhöht wurden. D PMID
  • Die Studie zeigte variierende Wechselwirkungsmuster zwischen Hopfentrensen gegenüber Bakterien und Hühnerei-Zellen mit einigen additiven und synergetischen Effekten. D PMID
  • Volatile Stoffe von Vishniacozyma victoria können die Bildung von Zitratrichomen bei Hopfen induzieren, wobei 2-Nonaonon ein wichtiger biologisch aktiver Bestandteil ist. D PMID
  • Eine Xanthohumol-Supplementation wurde mit einer verringerten Sekundärbilinsäurenmenge und erhöhtem IL-10 verbunden, was möglicherweise Symptome bei Patienten mit Chronenerkrankung verbessern könnte. B PMID

Frequently asked questions

What is Bine?

Bine (Humulus lupulus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Bine?

7 sourced findings are recorded for Bine; the strongest carries evidence grade B. For example: Xanthohumol in einer Dosis von 24 mg pro Tag wurde gut vertragen und zeigte geringe vorteilhafte Trends im BMI und der GGT bei Erwachsenen mit Chronischer Darmerkrankung.

How strong is the evidence for Bine?

The strongest finding for Bine carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).

Is Bine safe? What are the side effects?

No major safety issues are recorded for Bine in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Bine interact with medications?

No drug interactions are recorded for Bine in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Bine?

Bine is also known as: Хмель обыкновенный, houblon.

Is Bine a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Quellen

  1. T2 Safety and Tolerability of Xanthohumol in Adults With Crohn's Disease: Results of a Triple-Masked, Randomized, Placebo-Controlled Phase 2 Trial. literature abstract metadata
  2. T2 Modulation of Microbiota-Derived Bile Acids Linked to Symptom Amelioration in Crohn's Disease: Insights From a Randomized Clinical Trial With Xanthohumol Supplementation. literature abstract metadata
  3. T2 Volatile Compounds from Vishniacozyma victoriae Induce Glandular Trichome Development in Humulus lupulus. literature abstract metadata
  4. T2 Mixture dependent correlation patterns in antibacterial and cytotoxic activities of five hop isolates. literature abstract metadata
  5. T2 Protective Effects of Humulus lupulus L. Extract on CCl₄-Induced Nephrotoxicity in Rats. literature abstract metadata
  6. T2 Association-Based Analysis of Verticillium Wilt Resistance in a Bi-Parental Hop (Humulus lupulus L.) Population for Marker Development in Breeding. literature abstract metadata
  7. T2 Humulus lupulus L. in Animal Nutrition: Phytochemical Profile, Bioactive Properties, and Applications as a Functional Feed Additive-A Comprehensive Review. literature abstract metadata