Bine
Humulus lupulus
Humulus lupulus, commonly known as hops, is a traditional plant used primarily for brewing beer and has some historical use in herbal medicine. It is traditionally employed to aid sleep and relaxation but lacks specific documented uses in various traditions. Scientific evidence suggests that xanthohumol, a compound found in hops, at 24 mg/day was well-tolerated and showed minor beneficial trends in body mass index (BMI) and gamma-glutamyl transferase (GGT) levels in adults with Crohn's disease. Additionally, hop extracts demonstrated significant reductions in serum urea, creatinine, uric acid levels, and renal malondialdehyde (MDA), while increasing antioxidant activities like total antioxidant capacity (TAC), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in rats with CCl₄-induced nephrotoxicity. However, the evidence is limited and more research is needed to confirm these findings. No major safety issues or drug interactions have been recorded for hops, but further studies are warranted to fully understand its potential effects and applications.
- Best evidence
- B
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Xanthohumol at 24 mg/day was well-tolerated and showed minor beneficial trends in BMI and GGT in adults with Crohn's disease.
- Hops showed variable effects as feed additives in different animal species, with some benefits but also dose-dependent adverse impacts.
- GWAS did not identify significant SNPs but found several candidate loci, including a wall-associated kinase, for Verticillium wilt resistance in hop.
- Humulus lupulus extract significantly reduced serum urea, creatinine, uric acid levels and renal MDA while increasing TAC, CAT, SOD, and GPx activities in CCl₄-induced nephrotoxicity rats.
- The study found variable interaction patterns between hop isolates against bacteria and chicken cells, with some additive and synergistic effects observed.
- Volatile compounds from Vishniacozyma victoriae can induce glandular trichome formation in hops, with 2-nonanone being a key bioactive component.
- Xanthohumol supplementation was associated with reduced secondary bile acids and increased IL-10, potentially improving symptoms in Crohn's disease patients.
Frequently asked questions
What is Bine?
Bine (Humulus lupulus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Bine?
7 sourced findings are recorded for Bine; the strongest carries evidence grade B. For example: Xanthohumol at 24 mg/day was well-tolerated and showed minor beneficial trends in BMI and GGT in adults with Crohn's disease.
How strong is the evidence for Bine?
The strongest finding for Bine carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Bine safe? What are the side effects?
No major safety issues are recorded for Bine in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Bine interact with medications?
No drug interactions are recorded for Bine in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Bine?
Bine is also known as: Хмель обыкновенный, houblon.
Is Bine a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Safety and Tolerability of Xanthohumol in Adults With Crohn's Disease: Results of a Triple-Masked, Randomized, Placebo-Controlled Phase 2 Trial. literature abstract metadata
- T2 Modulation of Microbiota-Derived Bile Acids Linked to Symptom Amelioration in Crohn's Disease: Insights From a Randomized Clinical Trial With Xanthohumol Supplementation. literature abstract metadata
- T2 Volatile Compounds from Vishniacozyma victoriae Induce Glandular Trichome Development in Humulus lupulus. literature abstract metadata
- T2 Mixture dependent correlation patterns in antibacterial and cytotoxic activities of five hop isolates. literature abstract metadata
- T2 Protective Effects of Humulus lupulus L. Extract on CCl₄-Induced Nephrotoxicity in Rats. literature abstract metadata
- T2 Association-Based Analysis of Verticillium Wilt Resistance in a Bi-Parental Hop (Humulus lupulus L.) Population for Marker Development in Breeding. literature abstract metadata
- T2 Humulus lupulus L. in Animal Nutrition: Phytochemical Profile, Bioactive Properties, and Applications as a Functional Feed Additive-A Comprehensive Review. literature abstract metadata