FolkKB

Bine

Humulus lupulus

Humulus lupulus is a flowering plant central to various traditional herbal practices. It has been used historically as a nervine, sedative, and diuretic to address nervous complaints, sleeplessness, infections, and inflammation. Scientific evidence regarding its efficacy is limited and varied. While xanthohumol has shown minor beneficial trends in BMI and GGT in some adults with Crohn's disease, studies in animals show both potential benefits and dose-dependent adverse impacts. In rat models, extracts have appeared to reduce certain markers of nephrotoxicity. No major safety issues or notable drug interactions have been recorded.

At a glance
Traditionally for
sedative · diuretic
Traditions
Western phytotherapy · traditional · TCM
Best evidence
B
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

Traditional use

What the science says

  • Xanthohumol at 24 mg/day was well-tolerated and showed minor beneficial trends in BMI and GGT in adults with Crohn's disease. B PMID
  • Hops showed variable effects as feed additives in different animal species, with some benefits but also dose-dependent adverse impacts. D PMID
  • GWAS did not identify significant SNPs but found several candidate loci, including a wall-associated kinase, for Verticillium wilt resistance in hop. D PMID
  • Humulus lupulus extract significantly reduced serum urea, creatinine, uric acid levels and renal MDA while increasing TAC, CAT, SOD, and GPx activities in CCl₄-induced nephrotoxicity rats. D PMID
  • The study found variable interaction patterns between hop isolates against bacteria and chicken cells, with some additive and synergistic effects observed. D PMID
  • Volatile compounds from Vishniacozyma victoriae can induce glandular trichome formation in hops, with 2-nonanone being a key bioactive component. D PMID
  • Xanthohumol supplementation was associated with reduced secondary bile acids and increased IL-10, potentially improving symptoms in Crohn's disease patients. B PMID

Frequently asked questions

What is Bine?

Bine (Humulus lupulus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What is Bine traditionally used for?

Traditional sources record Bine for: sedative, diuretic, sleeplessness, infections, vermifuge, anodyne. This reflects traditional use, not a proven medical treatment.

Which traditions use Bine?

Bine appears in these traditions in our sources: Western phytotherapy, traditional, TCM.

What does the scientific evidence say about Bine?

7 sourced findings are recorded for Bine; the strongest carries evidence grade B. For example: Xanthohumol at 24 mg/day was well-tolerated and showed minor beneficial trends in BMI and GGT in adults with Crohn's disease.

How strong is the evidence for Bine?

The strongest finding for Bine carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).

Is Bine safe? What are the side effects?

No major safety issues are recorded for Bine in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Bine interact with medications?

No drug interactions are recorded for Bine in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Bine?

Bine is also known as: Хмель обыкновенный, houblon.

Is Bine a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T3 Dr. Duke's Ethnobotanical Database public domain (USDA ARS — attribute Dr. Duke's)
  2. T2 Safety and Tolerability of Xanthohumol in Adults With Crohn's Disease: Results of a Triple-Masked, Randomized, Placebo-Controlled Phase 2 Trial. literature abstract metadata
  3. T2 Modulation of Microbiota-Derived Bile Acids Linked to Symptom Amelioration in Crohn's Disease: Insights From a Randomized Clinical Trial With Xanthohumol Supplementation. literature abstract metadata
  4. T2 Volatile Compounds from Vishniacozyma victoriae Induce Glandular Trichome Development in Humulus lupulus. literature abstract metadata
  5. T2 Mixture dependent correlation patterns in antibacterial and cytotoxic activities of five hop isolates. literature abstract metadata
  6. T2 Protective Effects of Humulus lupulus L. Extract on CCl₄-Induced Nephrotoxicity in Rats. literature abstract metadata
  7. T2 Association-Based Analysis of Verticillium Wilt Resistance in a Bi-Parental Hop (Humulus lupulus L.) Population for Marker Development in Breeding. literature abstract metadata
  8. T2 Humulus lupulus L. in Animal Nutrition: Phytochemical Profile, Bioactive Properties, and Applications as a Functional Feed Additive-A Comprehensive Review. literature abstract metadata