FolkKB

Bine

Humulus lupulus

Humulus lupulus, commonly known as hops, is a traditional plant used primarily for brewing beer. While its use in traditional medicine has not been extensively documented, it has shown potential in various scientific studies. In adults with Crohn's disease, xanthohumol at 24 mg/day was well-tolerated and demonstrated minor beneficial trends regarding body mass index (BMI) and gamma-glutamyl transferase (GGT). Hops have also been explored as feed additives for different animal species, showing variable effects; while some benefits were observed, there were also dose-dependent adverse impacts. Genome-wide association studies (GWAS) did not identify significant single nucleotide polymorphisms (SNPs), but found several candidate loci, including a wall-associated kinase, associated with resistance to Verticillium wilt in hop plants. In a study using CCl₄-induced nephrotoxicity rats, Humulus lupulus extract significantly reduced serum urea and creatinine levels, decreased uric acid, and increased antioxidant activities such as TAC, CAT, SOD, and GPx. Safety concerns for Humulus lupulus are minimal based on current data. There have been no major issues recorded regarding its use. Similarly, there is currently no evidence of significant drug interactions associated with this plant.

De un vistazo
Mejor evidencia
B
Precauciones
—

Solo información. El uso tradicional no significa eficacia probada. La evidencia y la seguridad varían — consulte las fuentes citadas.

Lo que dice la ciencia

  • Xantohumol a una dosis de 24 mg/día se toleró bien y mostró tendencias beneficiosas menores en IMC y GGT en adultos con enfermedad de Crohn. B PMID
  • Los abedules mostraron efectos variables como aditivos alimenticios en diferentes especies animales, con algunos beneficios pero también impactos adversos dependientes de la dosis. D PMID
  • GWAS no identificó SNPs significativos, pero encontró varios locus candidatos, incluyendo una quinasa asociada a la pared celular, para la resistencia al mal de Verticillium en el hops. D PMID
  • El extracto de Humulus lupulus redujo significativamente los niveles de urea, creatinina y ácido úrico en el suero sanguíneo y las MDA en los riñones de ratas con toxicidad renal inducida por CCl₄, mientras que aumentó las actividades de TAC, CAT, SOD y GPx. D PMID
  • El estudio encontró patrones variables de interacción entre aislados de lúpulo contra bacterias y células de pollo, con efectos aditivos y sintéticos observados. D PMID
  • Los compuestos volátiles de Vishniacozyma victoria pueden inducir la formación de tricomas glandulares en el lúpulo, con 2-nonaeno siendo un componente bioactivamente clave. D PMID
  • La suplementación con xantohumol se asoció con una reducción de las acidez biliares secundarias y un aumento en el IL-10, lo que podría mejorar los síntomas en pacientes con enfermedad de Crohn. B PMID

Frequently asked questions

What is Bine?

Bine (Humulus lupulus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Bine?

7 sourced findings are recorded for Bine; the strongest carries evidence grade B. For example: Xantohumol a una dosis de 24 mg/día se toleró bien y mostró tendencias beneficiosas menores en IMC y GGT en adultos con enfermedad de Crohn.

How strong is the evidence for Bine?

The strongest finding for Bine carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).

Is Bine safe? What are the side effects?

No major safety issues are recorded for Bine in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Bine interact with medications?

No drug interactions are recorded for Bine in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Bine?

Bine is also known as: Хмель обыкновенный, houblon.

Is Bine a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Fuentes

  1. T2 Safety and Tolerability of Xanthohumol in Adults With Crohn's Disease: Results of a Triple-Masked, Randomized, Placebo-Controlled Phase 2 Trial. literature abstract metadata
  2. T2 Modulation of Microbiota-Derived Bile Acids Linked to Symptom Amelioration in Crohn's Disease: Insights From a Randomized Clinical Trial With Xanthohumol Supplementation. literature abstract metadata
  3. T2 Volatile Compounds from Vishniacozyma victoriae Induce Glandular Trichome Development in Humulus lupulus. literature abstract metadata
  4. T2 Mixture dependent correlation patterns in antibacterial and cytotoxic activities of five hop isolates. literature abstract metadata
  5. T2 Protective Effects of Humulus lupulus L. Extract on CCl₄-Induced Nephrotoxicity in Rats. literature abstract metadata
  6. T2 Association-Based Analysis of Verticillium Wilt Resistance in a Bi-Parental Hop (Humulus lupulus L.) Population for Marker Development in Breeding. literature abstract metadata
  7. T2 Humulus lupulus L. in Animal Nutrition: Phytochemical Profile, Bioactive Properties, and Applications as a Functional Feed Additive-A Comprehensive Review. literature abstract metadata