Big Leaf Mahogany
Swietenia macrophylla
Swietenia macrophylla, commonly known as bigleaf mahogany, is a tropical hardwood native to Central America and parts of South America. While its traditional medicinal uses are not well-documented in historical or cultural practices, scientific research has shown some promise. Studies indicate that swietenine from Swietenia macrophylla improved renal function and reduced fibrosis in diabetic nephropathy rats by enhancing autophagy. Additionally, atmospheric solids analysis probe mass spectrometry accurately classified this species with 100% accuracy, highlighting its potential for identification and authentication. In vitro and in silico studies suggest that the isolated limonoid swietenolide may have potential as an α-glucosidase inhibitor, though specific outcomes are not detailed here. Safety concerns do not appear to be significant based on current data, and there are no recorded drug interactions associated with Swietenia macrophylla.
- Beste Evidenz
- D
- Warnhinweise
- —
Nur zur Information. Traditionelle Anwendung bedeutet keine nachgewiesene Wirksamkeit. Evidenz und Sicherheit variieren — siehe die angegebenen Quellen.
Was die Wissenschaft sagt
- Swietenine verbesserte die Nierenfunktion und reduzierte die Fibrose bei Ratten mit diabetesmäßiger Nephropathie durch eine Steigerung der Autophagie.
- Dieses Studie zeigt eine Klassifizierungsgenauigkeit von 100 % an, indem ein kompaktes Massenspektrometer für die Identifikation viertel tropischer Holzarten, einschließlich Swietenia macrophylla, verwendet wird.
- Die Studie beschreibt die Anwendung der Vitrifikationskryopreservation für Swietenia macrophylla, obwohl spezifische Ergebnisse hier nicht detailliert werden.
- Der vom Swietenia macrophylla entzogene Limonenid Swietenolide zeigte Potenzial als α-Glucosidase-Inhibitör durch In-Vitro- und In-Silico-Studien.
Frequently asked questions
What is Big Leaf Mahogany?
Big Leaf Mahogany (Swietenia macrophylla) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Big Leaf Mahogany?
4 sourced findings are recorded for Big Leaf Mahogany; the strongest carries evidence grade D. For example: Swietenine verbesserte die Nierenfunktion und reduzierte die Fibrose bei Ratten mit diabetesmäßiger Nephropathie durch eine Steigerung der Autophagie.
How strong is the evidence for Big Leaf Mahogany?
The strongest finding for Big Leaf Mahogany carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Big Leaf Mahogany safe? What are the side effects?
No major safety issues are recorded for Big Leaf Mahogany in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Big Leaf Mahogany interact with medications?
No drug interactions are recorded for Big Leaf Mahogany in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Big Leaf Mahogany?
Big Leaf Mahogany is also known as: Acajou.
Is Big Leaf Mahogany a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Quellen
- T2 Real-Time Wood Chemotyping Using a Low-Cost and Compact Mass Spectrometer. literature abstract metadata
- T2 In silico and in vitro study for the limonoid isolated from Swietenia macrophylla as potential α-glucosidase inhibitor. literature abstract metadata
- T2 Long-Term Preservation by Cryopreservation Method Swietenia macrophylla King. literature abstract metadata
- T2 Swietenine Enhances Autophagy to Improve Renal Fibrosis via AMPK/mTOR/ULK1 Signaling Pathway in Diabetic Nephropathy. literature abstract metadata