Big Leaf Mahogany
Swietenia macrophylla
Swietenia macrophylla, commonly known as bigleaf mahogany, is a tropical hardwood native to Central America and parts of South America. While its traditional medicinal uses are not well-documented in historical or cultural practices, scientific research has shown some promise. Studies indicate that swietenine from Swietenia macrophylla improved renal function and reduced fibrosis in diabetic nephropathy rats by enhancing autophagy. Additionally, atmospheric solids analysis probe mass spectrometry accurately classified this species with 100% accuracy, highlighting its potential for identification and authentication. In vitro and in silico studies suggest that the isolated limonoid swietenolide may have potential as an α-glucosidase inhibitor, though specific outcomes are not detailed here. Safety concerns do not appear to be significant based on current data, and there are no recorded drug interactions associated with Swietenia macrophylla.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Swietenine improved renal function and reduced fibrosis in diabetic nephropathy rats by enhancing autophagy.
- This study demonstrates 100% classification accuracy using a compact mass spectrometer for identifying four tropical hardwood species, including Swietenia macrophylla.
- The study describes the application of vitrification cryopreservation for Swietenia macrophylla, though specific outcomes are not detailed here.
- Swietenia macrophylla's isolated limonoid swietenolide showed potential as an α-glucosidase inhibitor through in vitro and in silico studies.
Frequently asked questions
What is Big Leaf Mahogany?
Big Leaf Mahogany (Swietenia macrophylla) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Big Leaf Mahogany?
4 sourced findings are recorded for Big Leaf Mahogany; the strongest carries evidence grade D. For example: Swietenine improved renal function and reduced fibrosis in diabetic nephropathy rats by enhancing autophagy.
How strong is the evidence for Big Leaf Mahogany?
The strongest finding for Big Leaf Mahogany carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Big Leaf Mahogany safe? What are the side effects?
No major safety issues are recorded for Big Leaf Mahogany in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Big Leaf Mahogany interact with medications?
No drug interactions are recorded for Big Leaf Mahogany in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Big Leaf Mahogany?
Big Leaf Mahogany is also known as: Acajou.
Is Big Leaf Mahogany a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Real-Time Wood Chemotyping Using a Low-Cost and Compact Mass Spectrometer. literature abstract metadata
- T2 In silico and in vitro study for the limonoid isolated from Swietenia macrophylla as potential α-glucosidase inhibitor. literature abstract metadata
- T2 Long-Term Preservation by Cryopreservation Method Swietenia macrophylla King. literature abstract metadata
- T2 Swietenine Enhances Autophagy to Improve Renal Fibrosis via AMPK/mTOR/ULK1 Signaling Pathway in Diabetic Nephropathy. literature abstract metadata