Allophylus cobbe
Allophylus cobbe
Allophylus cobbe is a plant traditionally found in tropical regions of Africa, particularly in countries like Nigeria and Ghana. While it has not been widely used in traditional medicine, studies have shown potential biological activities. Scientific evidence indicates that Allophylus cobbe leaf extracts exhibit cytotoxic effects against liver cancer cells (HepG2), with IC50 values ranging from 9.388 to 19.95 μg/mL, suggesting possible anticancer activity. Additionally, the plant has shown potential antioxidant and antimicrobial properties, though further research is necessary to confirm these findings comprehensively. Extracts of Allophylus cobbe have also demonstrated varying degrees of antimicrobial activity against bacteria and fungi, with some significant inhibitions observed. Notably, no major safety concerns or reported drug interactions have been recorded for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Allophylus cobbe leaf extracts showed cytotoxic effects against HepG2 cells with IC50 values <100 μg/mL.
- The study found that Allophylus cobbe leaf extracts showed potential antioxidant and weak anticancer activity against prostate cancer cell lines without affecting normal cells, though further investigation is needed.
- The study found that silver nanoparticles synthesized using Allophylus cobbe leaf extract, when combined with conventional antibiotics, showed enhanced antibacterial and anti-biofilm activity against various human pathogenic bacteria.
- A new tocotrienol, 5-hydroxy-8-methyltocotrienol, was isolated from the roots and branches of Allophylus cobbe.
- The study found that extracts of Allophylus cobbe showed varying degrees of antimicrobial activity against bacteria and fungi, with some significant inhibitions observed.
Frequently asked questions
What is Allophylus cobbe?
Allophylus cobbe (Allophylus cobbe) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Allophylus cobbe?
5 sourced findings are recorded for Allophylus cobbe; the strongest carries evidence grade D. For example: Allophylus cobbe leaf extracts showed cytotoxic effects against HepG2 cells with IC50 values <100 μg/mL.
How strong is the evidence for Allophylus cobbe?
The strongest finding for Allophylus cobbe carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Allophylus cobbe safe? What are the side effects?
No major safety issues are recorded for Allophylus cobbe in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Allophylus cobbe interact with medications?
No drug interactions are recorded for Allophylus cobbe in our sources. This does not rule them out — check with a pharmacist.
Is Allophylus cobbe a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 In vitro antimicrobial and brine shrimp lethality of Allophylus cobbe L. literature abstract metadata
- T2 Enhanced antibacterial and anti-biofilm activities of silver nanoparticles against Gram-negative and Gram-positive bacteria. literature abstract metadata
- T2 Evaluation of in vitro antioxidant and anticancer activity of Allophylus cobbe leaf extracts on DU-145 and PC-3 human prostate cancer cell lines. literature abstract metadata
- T2 A new tocotrienol from the roots and branches of Allophylus cobbe (L.) Raeusch (Sapindaceae). literature abstract metadata
- T2 Cytotoxicity against Human Hepatocellular Carcinoma (HepG2) Cells and Anti-Oxidant Activity of Selected Endemic or Medicinal Plants in Sri Lanka. literature abstract metadata