Allophylus cobbe
Allophylus cobbe
Allophylus cobbe is a plant traditionally used in various folk medicine practices, particularly in parts of Africa and Asia. While its specific traditional uses are not well-documented, it has been studied for potential health benefits. Scientific evidence suggests that Allophylus cobbe leaf extracts may exhibit cytotoxic effects against certain cancer cells, specifically HepG2 cells, with IC50 values less than 100 μg/mL. Additionally, the plant shows potential antioxidant and weak anticancer activity against prostate cancer cell lines without affecting normal cells; however, further research is necessary to confirm these findings. Silver nanoparticles synthesized from Allophylus cobbe leaf extract have shown enhanced antibacterial and anti-biofilm activity when combined with conventional antibiotics against various human pathogenic bacteria. A new tocotrienol, 5-hydroxy-8-methyltocotrienol, has also been isolated from the roots and branches of the plant. No major safety issues or recorded drug interactions have been identified to date.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Allophylus cobbe leaf extracts showed cytotoxic effects against HepG2 cells with IC50 values <100 μg/mL.
- The study found that Allophylus cobbe leaf extracts showed potential antioxidant and weak anticancer activity against prostate cancer cell lines without affecting normal cells, though further investigation is needed.
- The study found that silver nanoparticles synthesized using Allophylus cobbe leaf extract, when combined with conventional antibiotics, showed enhanced antibacterial and anti-biofilm activity against various human pathogenic bacteria.
- A new tocotrienol, 5-hydroxy-8-methyltocotrienol, was isolated from the roots and branches of Allophylus cobbe.
- The study found that extracts of Allophylus cobbe showed varying degrees of antimicrobial activity against bacteria and fungi, with some significant inhibitions observed.
Frequently asked questions
What is Allophylus cobbe?
Allophylus cobbe (Allophylus cobbe) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Allophylus cobbe?
5 sourced findings are recorded for Allophylus cobbe; the strongest carries evidence grade D. For example: Allophylus cobbe leaf extracts showed cytotoxic effects against HepG2 cells with IC50 values <100 μg/mL.
How strong is the evidence for Allophylus cobbe?
The strongest finding for Allophylus cobbe carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Allophylus cobbe safe? What are the side effects?
No major safety issues are recorded for Allophylus cobbe in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Allophylus cobbe interact with medications?
No drug interactions are recorded for Allophylus cobbe in our sources. This does not rule them out — check with a pharmacist.
Is Allophylus cobbe a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 In vitro antimicrobial and brine shrimp lethality of Allophylus cobbe L. literature abstract metadata
- T2 Enhanced antibacterial and anti-biofilm activities of silver nanoparticles against Gram-negative and Gram-positive bacteria. literature abstract metadata
- T2 Evaluation of in vitro antioxidant and anticancer activity of Allophylus cobbe leaf extracts on DU-145 and PC-3 human prostate cancer cell lines. literature abstract metadata
- T2 A new tocotrienol from the roots and branches of Allophylus cobbe (L.) Raeusch (Sapindaceae). literature abstract metadata
- T2 Cytotoxicity against Human Hepatocellular Carcinoma (HepG2) Cells and Anti-Oxidant Activity of Selected Endemic or Medicinal Plants in Sri Lanka. literature abstract metadata