FolkKB

Java brucea

Brucea javanica

Brucea javanica is a plant traditionally used in some Asian herbal practices. While specific traditional uses for Brucea javanica are not well-documented, it has been studied for its potential antitumor properties. Scientific evidence suggests that PDVLNs (polymer-drug vesicle lipid nanoparticles) derived from Brucea javanica and other plants show promise as drug delivery systems in cancer treatment, particularly inhibiting oral squamous cell carcinoma by downregulating specific proteins. Studies indicate that combining traditional Chinese patent medicines with conventional chemotherapy may enhance the effectiveness of cancer treatment for advanced colorectal cancer patients. However, while the plant contains over 100 quassinoids with antitumor activity through various signaling pathways, challenges remain in formulation and safety. No major safety issues or drug interactions have been recorded to date.

At a glance
Best evidence
A
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • PDVLNs from various plants, including Brucea javanica, show potential in cancer treatment as drug delivery systems. D PMID
  • This study found that AS/BJO-NEs inhibited oral squamous cell carcinoma by downregulating CDK1, HOXC10, and MTFR2. D PMID
  • The study found that combining traditional Chinese patent medicines with conventional chemotherapy may improve disease control rate, objective response rate, and quality of life for advanced colorectal cancer patients. A PMID
  • The study found that Brucea javanica contains over 100 quassinoids with antitumor activity through various signaling pathways, but faces challenges in formulation and safety. D PMID

Frequently asked questions

What is Java brucea?

Java brucea (Brucea javanica) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Java brucea?

4 sourced findings are recorded for Java brucea; the strongest carries evidence grade A. For example: PDVLNs from various plants, including Brucea javanica, show potential in cancer treatment as drug delivery systems.

How strong is the evidence for Java brucea?

The strongest finding for Java brucea carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).

Is Java brucea safe? What are the side effects?

No major safety issues are recorded for Java brucea in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Java brucea interact with medications?

No drug interactions are recorded for Java brucea in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Java brucea?

Java brucea is also known as: Бруцея яванская.

Is Java brucea a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 Beneficial effects of proprietary Chinese medicines as adjuvant therapy in patients with advanced colorectal cancer: A meta-analysis. literature abstract metadata
  2. T2 The astragaloside-brucea javanica oil nanoemulsion inhibiting the progression of oral squamous cell carcinoma through CDK1- HOXC10-MTFR2 pathway. literature abstract metadata
  3. T2 Multi-dimensional insights into Brucea javanica (L.) Merr. in cancer treatment: current status, challenges and future directions. literature abstract metadata
  4. T2 Green nanomedicine for cancer therapy. literature abstract metadata