FolkKB

Blackdot

Cullen corylifolium

Cullen corylifolium, also known as Australian tea tree or lemon ironwood, is a plant native to Australia. While traditionally used in some indigenous practices for various purposes not well-documented, there is limited scientific evidence regarding its specific uses. In vitro studies have shown that three of the plant's isoflavones exhibit significant α-glucosidase inhibitory activity and four coumarins display varying cytotoxicity against certain cancer cell lines. Additionally, combined treatment with Reynoutria multiflora may exacerbate immune-mediated liver injury when compared to either herb used alone. The safety profile of Cullen corylifolium appears favorable as no major issues have been recorded; however, the scientific evidence is still limited and more research is needed. There are currently no reported drug interactions associated with this plant.

At a glance
Best evidence
D
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • Three isoflavones from Cullen corylifolium seeds showed significant in vitro α-glucosidase inhibitory activity. D PMID
  • Four coumarins from P. corylifolia showed varying cytotoxicity against A549 and MDA-MB-231 cells. D PMID
  • The combined treatment with Reynoutria multiflora and Cullen corylifolium may exacerbate immune-mediated liver injury compared to treatment with either herb alone. D PMID
  • Bakuchiol from Cullen corylifolium induced apoptosis and cell cycle arrest in HepG2 cells. D PMID

Frequently asked questions

What is Blackdot?

Blackdot (Cullen corylifolium) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Blackdot?

4 sourced findings are recorded for Blackdot; the strongest carries evidence grade D. For example: Three isoflavones from Cullen corylifolium seeds showed significant in vitro α-glucosidase inhibitory activity.

How strong is the evidence for Blackdot?

The strongest finding for Blackdot carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Blackdot safe? What are the side effects?

No major safety issues are recorded for Blackdot in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Blackdot interact with medications?

No drug interactions are recorded for Blackdot in our sources. This does not rule them out — check with a pharmacist.

Is Blackdot a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 Isolation, Cytotoxicity, and In-silico Screening of Coumarins from Psoralea corylifolia Linn. literature abstract metadata
  2. T2 Bakuchiol from Cullen corylifolium and its efficacy on apoptosis and autophagy in HepG2 cells. literature abstract metadata
  3. T2 Glycosidase inhibitory isoflavones from the seeds of Cullen corylifolium and their structure-activity relationship study. literature abstract metadata
  4. T2 A new incompatible combination: Reynoutria multiflora combined with Cullen corylifolium enhances idiosyncratic hepatotoxicity under immunological stress. literature abstract metadata