FolkKB

Blackdot

Cullen corylifolium

Cullen corylifolium, also known as Australian tea tree or lemon ironwood, is a plant native to Australia. While it has been used in traditional medicine for various purposes, no specific traditional uses have been recorded. Scientific evidence suggests that the combined use of Cullen corylifolium with Reynoutria multiflora might exacerbate immune-mediated liver injury compared to using either herb alone. Additionally, four coumarins from P. corylifolia demonstrated varying cytotoxicity against certain cell lines in vitro. Compounds isolated from its seeds showed significant in vitro α-glucosidase inhibitory effects and induced apoptosis and autophagy in HepG2 cells through multiple signaling pathways. No major safety issues or drug interactions have been reported, but further research is needed to fully understand its potential benefits and risks.

At a glance
Best evidence
D
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • Three isoflavones from Cullen corylifolium seeds showed significant in vitro α-glucosidase inhibitory activity. D PMID
  • Four coumarins from P. corylifolia showed varying cytotoxicity against A549 and MDA-MB-231 cells. D PMID
  • The combined treatment with Reynoutria multiflora and Cullen corylifolium may exacerbate immune-mediated liver injury compared to treatment with either herb alone. D PMID
  • Bakuchiol from Cullen corylifolium induced apoptosis and cell cycle arrest in HepG2 cells. D PMID

Frequently asked questions

What is Blackdot?

Blackdot (Cullen corylifolium) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Blackdot?

4 sourced findings are recorded for Blackdot; the strongest carries evidence grade D. For example: Three isoflavones from Cullen corylifolium seeds showed significant in vitro α-glucosidase inhibitory activity.

How strong is the evidence for Blackdot?

The strongest finding for Blackdot carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Blackdot safe? What are the side effects?

No major safety issues are recorded for Blackdot in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Blackdot interact with medications?

No drug interactions are recorded for Blackdot in our sources. This does not rule them out — check with a pharmacist.

Is Blackdot a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 Isolation, Cytotoxicity, and In-silico Screening of Coumarins from Psoralea corylifolia Linn. literature abstract metadata
  2. T2 Bakuchiol from Cullen corylifolium and its efficacy on apoptosis and autophagy in HepG2 cells. literature abstract metadata
  3. T2 Glycosidase inhibitory isoflavones from the seeds of Cullen corylifolium and their structure-activity relationship study. literature abstract metadata
  4. T2 A new incompatible combination: Reynoutria multiflora combined with Cullen corylifolium enhances idiosyncratic hepatotoxicity under immunological stress. literature abstract metadata