Curcuma zanthorrhiza
Curcuma zanthorrhiza
Curcuma zanthorrhiza is a traditional plant used in Southeast Asian medicine. While its specific uses are not well-documented, it has been included as part of the Xiao-Ai Jie-Du decoction, which traditionally addresses certain health conditions. Scientific evidence suggests potential benefits for type 2 diabetes mellitus through mechanisms involving SIRT1 activation and NFκB inhibition, though these findings are preliminary. In vitro studies indicate that (R)-(-)-Xanthorrhizol may inhibit cell migration and invasion in breast cancer cells. Additionally, the polyherbal extract of Curcuma zanthorrhiza showed significant reduction in liver enzyme levels and CYP450 expression in rats, hinting at possible hepatoprotective effects. To date, no major safety concerns or known drug interactions have been recorded for this plant, but further research is needed to confirm these findings comprehensively.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study identified curcumin and xanthorrhizol as potential SIRT1 activators and NFκB inhibitors, suggesting they might be useful in combating type 2 diabetes mellitus.
- (R)-(-)-Xanthorrhizol significantly inhibited MDA-MB-231 cell migration and invasion in a concentration-dependent manner by suppressing matrix metalloproteinases via the NF-κB signaling pathway.
- The study identified Curcuma zanthorrhiza as part of the core formula in Xiao-Ai Jie-Du decoction, which showed potential inhibition of DLBCL cell proliferation and induction of apoptosis.
- The highest dose of the polyherbal extract significantly reduced liver enzyme levels and CYP450 expression in rats.
Frequently asked questions
What is Curcuma zanthorrhiza?
Curcuma zanthorrhiza (Curcuma zanthorrhiza) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Curcuma zanthorrhiza?
4 sourced findings are recorded for Curcuma zanthorrhiza; the strongest carries evidence grade D. For example: The study identified curcumin and xanthorrhizol as potential SIRT1 activators and NFκB inhibitors, suggesting they might be useful in combating type 2 diabetes mellitus.
How strong is the evidence for Curcuma zanthorrhiza?
The strongest finding for Curcuma zanthorrhiza carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Curcuma zanthorrhiza safe? What are the side effects?
No major safety issues are recorded for Curcuma zanthorrhiza in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Curcuma zanthorrhiza interact with medications?
No drug interactions are recorded for Curcuma zanthorrhiza in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Curcuma zanthorrhiza?
Curcuma zanthorrhiza is also known as: Temu lawak.
Is Curcuma zanthorrhiza a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Computational evaluation of bioactive compounds in Curcuma zanthorrhiza targeting SIRT1 and NFκB. literature abstract metadata
- T2 Determination and mechanism of Xiao-Ai Jie-Du decoction against diffuse large B-cell lymphoma: In silico and In vitro studies. literature abstract metadata
- T2 (R)-(-)-Xanthorrhizol Inhibits the Migration and Invasion of Triple-Negative Breast Cancer Cells by Suppressing Matrix Metalloproteinases via the NF-κB Signaling Pathway. literature abstract metadata
- T2 Mitigating Tuberculosis Drug-induced Liver Injury: The Role of Moringa oleifera and Other Herbal Extracts. literature abstract metadata