Erythroxylum cuneatum
Erythroxylum cuneatum
Erythroxylum cuneatum, a plant native to Central America, has not been traditionally used for any specific medicinal purposes. Scientific evidence suggests that its alkaloid extract may have potential in managing morphine-related cellular adaptations and could offer antioxidant and anti-inflammatory benefits. In vitro studies also indicate cytotoxic activity against certain cancer cell lines without significant genotoxicity. No major safety concerns or drug interactions have been reported, but further research is needed to validate these findings comprehensively.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The alkaloid extract of Erythroxylum cuneatum upregulated proteins affected by chronic morphine, similar to methadone.
- Erythroxylum cuneatum alkaloid leaf extract showed antioxidant and anti-inflammatory activity in vitro and in a rat model.
- Erythroxylum cuneatum reduced morphine-induced cellular adaptation in neuroblastoma cells, similar to methadone.
- Erythroxylum cuneatum extract showed cytotoxic activity but no significant genotoxicity in human HepG2 and WRL68 cells.
Frequently asked questions
What is Erythroxylum cuneatum?
Erythroxylum cuneatum (Erythroxylum cuneatum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Erythroxylum cuneatum?
4 sourced findings are recorded for Erythroxylum cuneatum; the strongest carries evidence grade D. For example: The alkaloid extract of Erythroxylum cuneatum upregulated proteins affected by chronic morphine, similar to methadone.
How strong is the evidence for Erythroxylum cuneatum?
The strongest finding for Erythroxylum cuneatum carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Erythroxylum cuneatum safe? What are the side effects?
No major safety issues are recorded for Erythroxylum cuneatum in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Erythroxylum cuneatum interact with medications?
No drug interactions are recorded for Erythroxylum cuneatum in our sources. This does not rule them out — check with a pharmacist.
Is Erythroxylum cuneatum a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Assessment of genotoxicity and cytotoxicity of standardized aqueous extract from leaves of Erythroxylum cuneatum in human HepG2 and WRL68 cells line. literature abstract metadata
- T2 Morphine Antidependence of Erythroxylum cuneatum (Miq.) Kurz in Neurotransmission Processes In Vitro. literature abstract metadata
- T2 Antioxidant and anti-inflammatory properties of Erythroxylum cuneatum alkaloid leaf extract. literature abstract metadata
- T2 Erythroxylum cuneatum Prevented Cellular Adaptation in Morphineinduced Neuroblastoma Cells. literature abstract metadata