cockspurthorn
Maclura cochinchinensis
Maclura cochinchinensis, commonly known as the Chinese paper mulberry, is a plant traditionally used in East Asian medicine. While its specific traditional uses are not well-documented, studies have shown that heartwood extracts containing resveratrol and oxyresveratrol from this plant significantly inhibit melanogenesis in B16F10 melanoma cells. Additionally, ethyl acetate and n-hexane extracts, as well as resveratrol derived from Maclura cochinchinensis, exhibit significant cytotoxic, antioxidant, anti-inflammatory, and anti-migration activities against leukaemic cells. Synthesized derivatives of toxyloxanthone C and macluraxanthone also showed cytotoxicity against cancer cells and antibacterial activity. Scientific evidence suggests potential benefits in melanoma inhibition and anti-cancer properties, but more research is needed for definitive conclusions. No major safety issues or drug interactions have been recorded, though further studies are warranted to fully understand its effects and applications.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Maclura cochinchinensis heartwood extracts containing resveratrol and oxyresveratrol significantly inhibit melanogenesis in B16F10 melanoma cells.
- The study found that ethyl acetate and n-hexane extracts and resveratrol from Maclura cochinchinensis showed significant cytotoxic, antioxidant, anti-inflammatory, and anti-migration activities against leukaemic cells.
- Lupalbigenin, synthesized from Maclura cochinchinensis, showed rapid bactericidal activity and inhibited biofilm formation.
- The study synthesized derivatives of toxyloxanthone C and macluraxanthone from Maclura cochinchinensis, some exhibiting cytotoxicity against cancer cells and antibacterial activity.
Frequently asked questions
What is cockspurthorn?
cockspurthorn (Maclura cochinchinensis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about cockspurthorn?
4 sourced findings are recorded for cockspurthorn; the strongest carries evidence grade D. For example: Maclura cochinchinensis heartwood extracts containing resveratrol and oxyresveratrol significantly inhibit melanogenesis in B16F10 melanoma cells.
How strong is the evidence for cockspurthorn?
The strongest finding for cockspurthorn carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is cockspurthorn safe? What are the side effects?
No major safety issues are recorded for cockspurthorn in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does cockspurthorn interact with medications?
No drug interactions are recorded for cockspurthorn in our sources. This does not rule them out — check with a pharmacist.
Is cockspurthorn a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Biological activities of extracts and compounds from Thai Kae-Lae (Maclura cochinchinensis (Lour.) Corner). literature abstract metadata
- T2 Maclura cochinchinensis (Lour.) Corner Heartwood Extracts Containing Resveratrol and Oxyresveratrol Inhibit Melanogenesis in B16F10 Melanoma Cells. literature abstract metadata
- T2 Total synthesis and antibacterial evaluation of lupalbigenin and isolupalbigenin. literature abstract metadata
- T2 Structural modifications of toxyloxanthone C and macluraxanthone isolated from Maclura cochinchinensis: cytotoxicity, antibacterial activity, and in silico studies. literature abstract metadata