Rajmahal-creeper
Marsdenia tenacissima
Marsdenia tenacissima is a plant traditionally used in Chinese medicine, particularly within the practices of traditional Chinese and Korean medicine. It has been studied for its potential anti-cancer properties, with evidence suggesting it may enhance the effectiveness of chemotherapy in certain types of cancer. Specifically, studies have shown that combining Marsdenia tenacissima with chemotherapy can improve objective response rates in advanced non-small cell lung cancer (NSCLC). Additionally, isolated steroidal glycosides from the plant demonstrated significant inhibitory effects on CYP3A4 enzymatic activity and showed potential as an adjunct to standard chemotherapy for gastric cancer. However, evidence remains heterogeneous, indicating a need for further research. No major safety issues or drug interactions have been recorded, but caution is advised due to limited clinical data.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Marsdenia tenacissima combined with chemotherapy showed improved objective response rates compared to chemotherapy alone in advanced NSCLC.
- Seven undescribed steroidal glycosides were isolated from Marsdenia tenacissima and showed statistically significant inhibitory effects on CYP3A4 enzymatic activity.
- Tongguanteng Injection induces G2/M phase arrest and ferroptosis in breast cancer cells by targeting the AURKA/KEAP1/NRF2 axis.
- Marsdenia tenacissima's phytocompounds showed potential as an adjunct to standard chemotherapy for gastric cancer, though evidence remains heterogeneous.
Frequently asked questions
What is Rajmahal-creeper?
Rajmahal-creeper (Marsdenia tenacissima) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Rajmahal-creeper?
4 sourced findings are recorded for Rajmahal-creeper; the strongest carries evidence grade A. For example: Marsdenia tenacissima combined with chemotherapy showed improved objective response rates compared to chemotherapy alone in advanced NSCLC.
How strong is the evidence for Rajmahal-creeper?
The strongest finding for Rajmahal-creeper carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Rajmahal-creeper safe? What are the side effects?
No major safety issues are recorded for Rajmahal-creeper in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Rajmahal-creeper interact with medications?
No drug interactions are recorded for Rajmahal-creeper in our sources. This does not rule them out — check with a pharmacist.
Is Rajmahal-creeper a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Economics, efficacy and safety of five traditional Chinese medicine injections plus chemotherapy as adjuvant therapy for non-small cell lung cancer: A network meta-analysis. literature abstract metadata
- T2 Synergistic Interactions Between Medicinal Plant Bioactive and Standard Chemotherapy in Gastric Cancer: Preclinical Evidence and Translational Pitfalls. literature abstract metadata
- T2 Tongguanteng injection induces cell cycle arrest and drives ferroptosis through AURKA/KEAP1/NRF2 axis in breast cancer. literature abstract metadata
- T2 Seven undescribed steroidal glycosides with CYP3A4 inhibitory activity from the stems of Marsdenia tenacissima. literature abstract metadata