Balsam Pear
Momordica cochinchinensis
Momordica cochinchinensis, commonly known as gac fruit, originates from Southeast Asia and is used in traditional medicine practices. Traditionally, it has not been extensively documented for specific uses; however, its various parts have shown potential benefits in scientific studies. Extracts from the fruit showed significant protection against β-Amyloid-induced toxicity by enhancing synaptic functions in HT-22 cells, indicating possible neuroprotective effects. Additionally, methanolic extracts demonstrated hepatoprotective properties against acetaminophen (APAP)-induced liver injury through multiple mechanisms. Furthermore, chloroform-methanol soluble parts inhibited the proliferation, migration, and invasion of oral squamous cell carcinoma (OSCC) cells in vitro and reduced tumor growth in mice by targeting the JAK2/STAT3/c-Myc pathway. An optimized process for obtaining high-purity Momordica cochinchinensis protein concentrate was developed, which could be useful in functional foods and supplements. No major safety issues or known drug interactions have been recorded, though further research is warranted to fully understand its potential applications.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- PE-EtOH and SE-EtOAc from gac fruit parts extracts showed significant protection against β-Amyloid-induced toxicity by enhancing synaptic functions in HT-22 cells.
- MC exhibited hepatoprotective effects against APAP-induced liver injury through multiple mechanisms.
- CMSP inhibited proliferation, migration, and invasion of OSCC cells and reduced tumor growth in mice by targeting the JAK2/STAT3/c-Myc pathway.
- The study developed an optimized process for obtaining high-purity Momordica cochinchinensis protein concentrate with unique properties, potentially useful in functional foods and supplements.
Frequently asked questions
What is Balsam Pear?
Balsam Pear (Momordica cochinchinensis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Balsam Pear?
4 sourced findings are recorded for Balsam Pear; the strongest carries evidence grade D. For example: PE-EtOH and SE-EtOAc from gac fruit parts extracts showed significant protection against β-Amyloid-induced toxicity by enhancing synaptic functions in HT-22 cells.
How strong is the evidence for Balsam Pear?
The strongest finding for Balsam Pear carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Balsam Pear safe? What are the side effects?
No major safety issues are recorded for Balsam Pear in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Balsam Pear interact with medications?
No drug interactions are recorded for Balsam Pear in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Balsam Pear?
Balsam Pear is also known as: Гак.
Is Balsam Pear a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Hepatoprotective Effects of Gac (Momordica cochinchinensis) Aril Extract in Acetaminophen-Induced Liver Injury: Modulation of Oxidative Stress, Inflammation, and Glucose Metabolism. literature abstract metadata
- T2 CMSP suppresses oral squamous cell carcinoma progression by targeting the JAK2/STAT3/c-Myc axis. literature abstract metadata
- T2 Neuroprotective Effect of Fresh Gac Fruit Parts Against β-Amyloid-Induced Toxicity and Its Influence on Synaptic Gene Expression in HT-22 Cell Model. literature abstract metadata
- T2 Production, characterization, and functional properties of protein concentrate from Momordica cochinchinensis seeds. literature abstract metadata