Chinese Peony

Paeonia lactiflora, commonly known as white peony or bai shao in traditional Chinese medicine, is traditionally used for its purported effects on blood regulation and pain relief. While specific uses vary across different traditions, it has been employed in East Asian practices for centuries. Scientific evidence suggests that paeoniflorin, a compound found in Paeonia lactiflora, may upregulate SOCS3 expression in macrophages, potentially reducing inflammation in osteoarthritis models. Additionally, extracellular vesicles derived from the plant have shown promise in improving diabetic peripheral neuropathy by modulating the CCL21/CCR7 axis and reducing Schwann cell injury and neuroinflammation. Other studies indicate that albiflorin, another compound from Paeonia lactiflora, can reduce the viability, proliferation, and migration of renal cell carcinoma cells through suppression of EGFR/MAPK signaling, with multiple pharmacological activities including anti-inflammatory, neuroprotective, and hepatoprotective effects. However, optimal oral bioavailability remains uncertain due to limited clinical data. No major safety issues or recorded drug interactions have been identified for Paeonia lactiflora thus far.

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.