Chinese silk vine

Periploca sepium, also known as Chinese rattan or climbing false buckthorn, originates from traditional Chinese medicine (TCM) and is found in various regions of China. Traditionally, it has not been extensively used for specific medicinal purposes. However, recent scientific studies have identified two genes, PsCYP87 and Ps14βPH, involved in cardenolide biosynthesis within the plant, suggesting potential evolutionary mechanisms. Additionally, root oils from Periploca sepium showed selective inhibition of mushroom-tyrosinase diphenolase activity while preserving monophenolase activity, indicating possible skin-related applications. While nine studies suggest that Longdan Xiegan formula, which includes Periploca sepium among other herbs, may help in managing hypertension symptoms and risk factors, the evidence is based on a synthesis of meta-analyses and requires further high-quality research to confirm these findings. TCM interventions involving Periploca sepium have been shown to significantly improve outcomes related to diabetic foot ulcers (DFU), as evidenced by a synthesis of meta-analyses. No major safety issues or drug interactions have been recorded for this plant, though comprehensive clinical trials are still needed to fully understand its potential benefits and risks.

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.