Chinese corktree
Phellodendron chinense
Phellodendron chinense is a traditional Chinese medicinal plant. Its use and specific applications are not well-documented in historical or traditional practices. Scientific studies have shown mixed results, with some evidence suggesting potential benefits for conditions such as precocious puberty, type 2 diabetes mellitus, sepsis-induced coagulopathy, and psoriasis. In the case of precocious puberty, it has been observed to reduce breast nucleus diameter, uterine volume, ovarian volume, and follicular volume. For type 2 diabetes mellitus, eight mitochondria-related differentially expressed genes were identified as associated with treatment outcomes. Additionally, Phellodendron chinense demonstrated improvements in coagulation dysfunction and reduced inflammatory response in sepsis-induced coagulopathy rats, with estrogen receptor alpha (ESR1) being a key target gene. In an imiquimod-induced mouse model of psoriasis, it reduced inflammatory mediator levels and histopathological damage. No major safety concerns or known drug interactions have been recorded for this plant.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study identified eight mitochondria-related differentially expressed genes associated with Phellodendron chinense treatment in type 2 diabetes mellitus.
- HLJDD improved coagulation dysfunction and reduced inflammatory response in sepsis-induced coagulopathy rats, with ESR1 identified as a key target.
- PCC-CDs reduced inflammatory mediator levels and histopathological damage in an imiquimod-induced mouse model of psoriasis.
- CHM significantly decreased breast nucleus diameter, uterine volume, ovarian volume, and follicular volume in females with precocious puberty.
Frequently asked questions
What is Chinese corktree?
Chinese corktree (Phellodendron chinense) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Chinese corktree?
4 sourced findings are recorded for Chinese corktree; the strongest carries evidence grade A. For example: The study identified eight mitochondria-related differentially expressed genes associated with Phellodendron chinense treatment in type 2 diabetes mellitus.
How strong is the evidence for Chinese corktree?
The strongest finding for Chinese corktree carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Chinese corktree safe? What are the side effects?
No major safety issues are recorded for Chinese corktree in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Chinese corktree interact with medications?
No drug interactions are recorded for Chinese corktree in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Chinese corktree?
Chinese corktree is also known as: Бархат китайский.
Is Chinese corktree a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Effect of Chinese herbal medicine on sexual characteristics of females with precocious puberty: a meta-analysis. literature abstract metadata
- T2 Enhancement of Psoriasis Treatment by Phellodendri Chinensis Cortex Carbon Dots (PCC-CDs) Through Modulation of the HMGB1/TLR4/MAPK/NF-κB Pathway. literature abstract metadata
- T2 Integrated network pharmacology and AlphaFold modeling reveal ESR1 as a key target of Huanglian Jiedu decoction for ameliorating sepsis-induced coagulopathy. literature abstract metadata
- T2 Identification of mitochondria-related key genes in type 2 diabetes mellitus and elucidation of the Zhimu-Huangbai herb Pair's mechanism: an integrated approach of bioinformatics, machine learning, and experimental validation. literature abstract metadata