FolkKB

Physochlaina

Physochlaina

Physochlaina, a plant traditionally with no recorded uses, has shown potential in modern scientific research. Studies have identified its roots as a source of cytotoxic activity against HeLa cervical cancer cells and modulating the JAK2/STAT3 pathway to mitigate chronic atrophic gastritis. Additionally, nine new steroidal saponins were isolated from Physochlaina physaloides, with infundilide A demonstrating significant anti-inflammatory effects in both cell and mouse models. The n-butanol fraction of Physochlaina physaloides also showed protective effects on gastric injury by regulating the PPAR/NF-κB signalling pathway in rats. Safety concerns are currently minimal, with no major issues recorded; however, further research is needed to confirm these findings. There are no reported drug interactions at this time.

At a glance
Best evidence
D
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • Physochloside D, a compound from P. physaloides, modulates the JAK2/STAT3 signaling pathway to suppress apoptosis and intestinal metaplasia in CAG. D PMID
  • The optimized ultrasound-assisted extraction of total flavonoids from Physochlaina physaloides roots showed cytotoxic activity against HeLa cervical cancer cells. D PMID
  • The study identified nine new steroidal saponins from Physochlainae Radix and found that infundilide A showed anti-inflammatory effects in both cell and mouse models. D PMID
  • The n-butanol fraction of Physochlaina physaloides (BPP) showed protective effects on gastric injury by regulating the PPAR/NF-κB signalling pathway in rats. D PMID

Frequently asked questions

What is Physochlaina?

Physochlaina (Physochlaina) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Physochlaina?

4 sourced findings are recorded for Physochlaina; the strongest carries evidence grade D. For example: Physochloside D, a compound from P. physaloides, modulates the JAK2/STAT3 signaling pathway to suppress apoptosis and intestinal metaplasia in CAG.

How strong is the evidence for Physochlaina?

The strongest finding for Physochlaina carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Physochlaina safe? What are the side effects?

No major safety issues are recorded for Physochlaina in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Physochlaina interact with medications?

No drug interactions are recorded for Physochlaina in our sources. This does not rule them out — check with a pharmacist.

What are the common names of Physochlaina?

Physochlaina is also known as: Пузырница.

Is Physochlaina a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 Revealing the gastric protective mechanism of Physochlaina physaloides (L) G. Don. with clinical orientation: PPAR/NF-κB signalling pathway activation. literature abstract metadata
  2. T2 New steroidal saponins from Physochlainae Radix: Structures and anti-inflammatory efficacy. literature abstract metadata
  3. T2 Integrating network pharmacology, pharmacokinetics and experimental validation to reveal the potential mechanism of Physochlaina physaloides (L.) G. Don in chronic atrophic gastritis. literature abstract metadata
  4. T2 Optimized ultrasound extraction and cytotoxic activity against HeLa cervical cancer cells of total flavonoids of Physochlaina physaloides (L.) G. Don. literature abstract metadata