Physochlaina
Physochlaina
Physochlaina, a traditional medicine plant, primarily originates from its roots and is traditionally used in few documented practices. Scientific studies have shown promising results with Physochlaina physaloides, indicating cytotoxic activity against HeLa cervical cancer cells through the optimized ultrasound-assisted extraction of total flavonoids. Additionally, Physochloside D modulates the JAK2/STAT3 signaling pathway to suppress apoptosis and intestinal metaplasia in CAG models. The plant has also yielded nine new steroidal saponins, with infundilide A exhibiting anti-inflammatory effects both in cell cultures and mouse models. Furthermore, the n-butanol fraction of Physochlaina physaloides demonstrated protective effects on gastric injury by regulating the PPAR/NF-κB signaling pathway in rats. To date, no major safety concerns or recorded drug interactions have been identified for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Physochloside D, a compound from P. physaloides, modulates the JAK2/STAT3 signaling pathway to suppress apoptosis and intestinal metaplasia in CAG.
- The optimized ultrasound-assisted extraction of total flavonoids from Physochlaina physaloides roots showed cytotoxic activity against HeLa cervical cancer cells.
- The study identified nine new steroidal saponins from Physochlainae Radix and found that infundilide A showed anti-inflammatory effects in both cell and mouse models.
- The n-butanol fraction of Physochlaina physaloides (BPP) showed protective effects on gastric injury by regulating the PPAR/NF-κB signalling pathway in rats.
Frequently asked questions
What is Physochlaina?
Physochlaina (Physochlaina) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Physochlaina?
4 sourced findings are recorded for Physochlaina; the strongest carries evidence grade D. For example: Physochloside D, a compound from P. physaloides, modulates the JAK2/STAT3 signaling pathway to suppress apoptosis and intestinal metaplasia in CAG.
How strong is the evidence for Physochlaina?
The strongest finding for Physochlaina carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Physochlaina safe? What are the side effects?
No major safety issues are recorded for Physochlaina in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Physochlaina interact with medications?
No drug interactions are recorded for Physochlaina in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Physochlaina?
Physochlaina is also known as: Пузырница.
Is Physochlaina a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Revealing the gastric protective mechanism of Physochlaina physaloides (L) G. Don. with clinical orientation: PPAR/NF-κB signalling pathway activation. literature abstract metadata
- T2 New steroidal saponins from Physochlainae Radix: Structures and anti-inflammatory efficacy. literature abstract metadata
- T2 Integrating network pharmacology, pharmacokinetics and experimental validation to reveal the potential mechanism of Physochlaina physaloides (L.) G. Don in chronic atrophic gastritis. literature abstract metadata
- T2 Optimized ultrasound extraction and cytotoxic activity against HeLa cervical cancer cells of total flavonoids of Physochlaina physaloides (L.) G. Don. literature abstract metadata