Picrorrhiza
Picrorhiza kurroa
Picrorhiza kurroa is a traditional medicinal plant primarily used in Ayurvedic practices, particularly in India. It has been traditionally employed for various health conditions but specific uses are not well-documented. Scientific evidence suggests that Picrorhiza kurroa contains therapeutic phytomolecules with potential anti-inflammatory and cardioprotective effects, though the data is limited and more research is needed to fully understand its mechanisms of action. The extract Androsin has shown promise in inhibiting colorectal cancer cell proliferation and invasion, but further studies are required to confirm these findings. No significant safety concerns or drug interactions have been reported for Picrorhiza kurroa, though this does not necessarily imply complete safety across all uses and populations.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The review highlights notable therapeutic phytomolecules from Picrorhiza kurroa, with some actions underexplored.
- Individual extracts of Picrorhiza kurroa and other botanicals in AYUSH-64 showed stronger anti-inflammatory effects compared to the formulation itself.
- BP1 treatment showed cardioprotective effects in zebrafish models of cardiac damage from ISO and DOX, involving multiple pathways.
- Androsin, extracted from Picrorhiza kurroa, inhibits colorectal cancer cell proliferation and invasion via different signaling pathways at low and high concentrations.
Frequently asked questions
What is Picrorrhiza?
Picrorrhiza (Picrorhiza kurroa) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Picrorrhiza?
4 sourced findings are recorded for Picrorrhiza; the strongest carries evidence grade D. For example: The review highlights notable therapeutic phytomolecules from Picrorhiza kurroa, with some actions underexplored.
How strong is the evidence for Picrorrhiza?
The strongest finding for Picrorrhiza carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Picrorrhiza safe? What are the side effects?
No major safety issues are recorded for Picrorrhiza in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Picrorrhiza interact with medications?
No drug interactions are recorded for Picrorrhiza in our sources. This does not rule them out — check with a pharmacist.
Is Picrorrhiza a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Journey from phytomolecules to bioactive molecules: a phytopharmacological exploration of botanicals and standardised extract of Picrorhiza kurroa. literature abstract metadata
- T2 Androsin alleviates colorectal cancer by inhibiting the PI3K/Akt-centered signaling pathway. literature abstract metadata
- T2 Individual Botanicals Perform Better than AYUSH-64 Formulation in Suppressing TLR4-Driven Inflammatory Cytokines. literature abstract metadata
- T2 Multiomics Analysis Reveals the Protective Effect of a Novel Bioactive Peptide (BP1) in Cardiomyopathy Using a Zebrafish Model. literature abstract metadata