Premna obtusifolia
Premna obtusifolia
Premna obtusifolia is a plant traditionally used in various folk medicine practices, though specific traditional applications have not been well-documented. Modern pharmacological studies have confirmed some ethno-medicinal claims about Premna integrifolia (which may be closely related or identical to P. obtusifolia), but the active constituents and their biological actions require further validation. A study determined the crystal structure of 7β-hydroxy-royleanone from Taxodium ascendens, though the absolute stereochemistry could not be definitively established; in contrast, the absolute configurations of Premna obtusifolia's title compound were found to be 4bS, 8aS, and 10R. Notably, 7-acetylhorminone derived from Premna obtusifolia showed potent cytotoxic efficacy against human colorectal carcinoma cell lines, though the broader implications of this finding remain to be explored. No major safety issues or drug interactions have been recorded for Premna obtusifolia thus far.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Many ethno-medicinal claims about Premna integrifolia have been confirmed through modern pharmacological studies, but the active constituents and biological actions need further validation.
- The crystal structure of 7β-hydroxy-royleanone from Taxodium ascendens was determined, but the absolute stereochemistry could not be definitively established.
- The absolute configurations of Premna obtusifolia's title compound were determined to be 4bS, 8aS, and 10R.
- The study found that 7-acetylhorminone, derived from Premna obtusifolia, showed potent cytotoxic efficacy against human colorectal carcinoma cell lines.
- Both Premna obtusifolia and Premna latifolia showed anti-inflammatory potential in rats, with P. latifolia being more effective.
Frequently asked questions
What is Premna obtusifolia?
Premna obtusifolia (Premna obtusifolia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Premna obtusifolia?
5 sourced findings are recorded for Premna obtusifolia; the strongest carries evidence grade D. For example: Many ethno-medicinal claims about Premna integrifolia have been confirmed through modern pharmacological studies, but the active constituents and biological actions need further validation.
How strong is the evidence for Premna obtusifolia?
The strongest finding for Premna obtusifolia carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Premna obtusifolia safe? What are the side effects?
No major safety issues are recorded for Premna obtusifolia in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Premna obtusifolia interact with medications?
No drug interactions are recorded for Premna obtusifolia in our sources. This does not rule them out — check with a pharmacist.
Is Premna obtusifolia a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Redetermination and absolute configuration of 7α-hy-droxy-royleanone. literature abstract metadata
- T2 A comparative experimental evaluation of anti-inflammatory activity of Premna obtusifolia Linn and Premna latifolia Roxb leaves in Charles foster rats. literature abstract metadata
- T2 Pharmacological potentials of Premna integrifolia L. literature abstract metadata
- T2 Crystal structure of 7β-hy-droxy-royleanone isolated from Taxodium ascendens (B.). literature abstract metadata
- T2 Inhibition of Human Colorectal Cancer by a Natural Product 7-Acetylhorminone and Interactions with BSA/HSA: Multispectral Analysis and In Silico and In Vitro Studies. literature abstract metadata