Devil's-Pepper
Rauvolfia
Rauvolfia is a genus of plants found in various tropical regions. There are no recorded traditional uses for this plant genus. Scientific evidence regarding Rauvolfia serpentina seed extract suggests potential anti-pseudomonal activity through interference with quorum sensing and biofilm formation in P. aeruginosa. Additionally, Rauvolfia vomitoria has shown notable hypoglycemic activity in studies of West African antidiabetic plants, though this requires further scientific validation. Research has also identified specific genes involved in secondary metabolite biosynthesis and elucidated mechanisms for scaffold formation. No major safety issues or notable drug interactions are currently recorded.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Rauvolfia serpentina seed extract showed anti-pseudomonal activity by interfering with quorum sensing and biofilm formation in P. aeruginosa.
- The study identifies key genes, including STR1, ABI3/VP1, and WRKY25, involved in secondary metabolite biosynthesis and root development in Rauvolfia serpentina.
- The study elucidated the mechanistic details of RsSTR-catalyzed reaction between 1-IEA and secologanin to form a rare piperazinyl-indole scaffold.
- This study identified Rauvolfia vomitoria among twelve antidiabetic plants commonly used in West African traditional medicine, showing notable hypoglycemic activity but requiring further scientific validation.
Frequently asked questions
What is Devil's-Pepper?
Devil's-Pepper (Rauvolfia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Devil's-Pepper?
4 sourced findings are recorded for Devil's-Pepper; the strongest carries evidence grade D. For example: Rauvolfia serpentina seed extract showed anti-pseudomonal activity by interfering with quorum sensing and biofilm formation in P. aeruginosa.
How strong is the evidence for Devil's-Pepper?
The strongest finding for Devil's-Pepper carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Devil's-Pepper safe? What are the side effects?
No major safety issues are recorded for Devil's-Pepper in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Devil's-Pepper interact with medications?
No drug interactions are recorded for Devil's-Pepper in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Devil's-Pepper?
Devil's-Pepper is also known as: Раувольфия.
Is Devil's-Pepper a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Comparative transcriptome analysis reveals ABI3/VP1-WRKY25-STR1 regulatory module linking specialized metabolism with root system development and stress response in Rauvolfia serpentina. literature abstract metadata
- T2 Diabetes mellitus in ECOWAS: an overview of the safety and efficacy of medicinal plants used in traditional medicine practices. literature abstract metadata
- T2 Disruption in Quorum-Sensing Circuits and Biofilm Matrix in Pseudomonas aeruginosa by Super-Critical CO2 Extracted Oleoresins From Rauvolfia serpentina Seeds Rescue Caenorhabditis elegans Model of Infection. literature abstract metadata
- T2 Mechanistic elucidation of strictosidine synthase-catalyzed Pictet-Spengler reaction for rare piperazine-indole scaffold formation. literature abstract metadata