Rehmannia
Rehmannia
Rehmannia, a traditional Chinese medicinal plant, is primarily used within the framework of Traditional Chinese Medicine (TCM) and other East Asian healing practices. It has been traditionally employed for its purported effects on blood tonification and yin nourishment, though specific recorded uses vary widely. Scientific evidence suggests that Rehmannia components such as rehmannioside D may prevent estrogen-deficiency-induced osteoporosis by inhibiting osteoclastogenesis and inducing their apoptosis. Additionally, SWHQD (a compound derived from Rehmannia) has shown potential in suppressing colorectal cancer through NCOA4/FTH1-mediated ferritinophagy-induced ferroptosis. Furthermore, six key components identified in Rehmannia-based Taohong Siwu Decoction have been proposed as quality markers for its antithrombotic effects. Research also indicates that REA treatment can improve cognitive functions and reduce neuronal loss following traumatic brain injury (TBI) by suppressing microglial activation. No major safety issues or drug interactions have been recorded, suggesting a generally safe profile when used appropriately. However, due to the limited data available, further research is necessary to fully understand its efficacy and potential applications in modern medicine.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- REA treatment improved cognitive functions and reduced neuronal loss in TBI mice by suppressing microglial activation.
- Rehmannioside D prevents estrogen-deficiency-induced osteoporosis by inhibiting osteoclastogenesis and inducing their apoptosis through dual mechanisms.
- SWHQD suppresses colorectal cancer through NCOA4/FTH1-mediated ferritinophagy-induced ferroptosis.
- This study identified six key components in Rehmannia-based Taohong Siwu Decoction as potential Q-Markers for its antithrombotic effects.
Frequently asked questions
What is Rehmannia?
Rehmannia (Rehmannia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Rehmannia?
4 sourced findings are recorded for Rehmannia; the strongest carries evidence grade D. For example: REA treatment improved cognitive functions and reduced neuronal loss in TBI mice by suppressing microglial activation.
How strong is the evidence for Rehmannia?
The strongest finding for Rehmannia carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Rehmannia safe? What are the side effects?
No major safety issues are recorded for Rehmannia in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Rehmannia interact with medications?
No drug interactions are recorded for Rehmannia in our sources. This does not rule them out — check with a pharmacist.
Is Rehmannia a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Rehmannioside A alleviates neuroinflammation and cognitive impairments after traumatic brain injury by suppressing microglial activation via the MAPK/NF-κB pathway. literature abstract metadata
- T2 A multidimensional integrated strategy for identifying anti-thrombotic quality markers(Q-Markers) in Taohong Siwu decoction through combined analysis of chemical profiling, bioactivity, and pharmacodynamic efficacy. literature abstract metadata
- T2 Sanwu Huangqin decoction induces ferroptosis in colorectal cancer cells by triggering NCOA4/FTH1-mediated ferritinophagy. literature abstract metadata
- T2 Rehmannioside D prevents estrogen-deficiency induced osteoporosis by interacting with c-Jun to dismantle the AP-1 complex and suppress MAPK/NF-κB signaling. literature abstract metadata