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Rehmannia

Rehmannia

Rehmannia, including species such as Rehmannia glutinosa, is a plant central to Traditional Chinese Medicine. It is traditionally utilized for blood support and nourishing yin. Scientific studies suggest potential therapeutic properties, such as Rehmannioside D's ability to inhibit osteoclastogenesis in osteoporosis models and the capacity of SWHQD to suppress colorectal cancer via ferroptosis. Research also indicates potential cognitive benefits following traumatic brain injury and antithrombotic effects in certain decoctions. No major safety issues or notable drug interactions are currently recorded in the available data.

At a glance
Traditionally for
blood support
Traditions
TCM
Best evidence
D
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

Traditional use

What the science says

  • REA treatment improved cognitive functions and reduced neuronal loss in TBI mice by suppressing microglial activation. D PMID
  • Rehmannioside D prevents estrogen-deficiency-induced osteoporosis by inhibiting osteoclastogenesis and inducing their apoptosis through dual mechanisms. D PMID
  • SWHQD suppresses colorectal cancer through NCOA4/FTH1-mediated ferritinophagy-induced ferroptosis. D PMID
  • This study identified six key components in Rehmannia-based Taohong Siwu Decoction as potential Q-Markers for its antithrombotic effects. D PMID

Frequently asked questions

What is Rehmannia?

Rehmannia (Rehmannia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What is Rehmannia traditionally used for?

Traditional sources record Rehmannia for: blood support. This reflects traditional use, not a proven medical treatment.

Which traditions use Rehmannia?

Rehmannia appears in these traditions in our sources: TCM.

What does the scientific evidence say about Rehmannia?

4 sourced findings are recorded for Rehmannia; the strongest carries evidence grade D. For example: REA treatment improved cognitive functions and reduced neuronal loss in TBI mice by suppressing microglial activation.

How strong is the evidence for Rehmannia?

The strongest finding for Rehmannia carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Rehmannia safe? What are the side effects?

No major safety issues are recorded for Rehmannia in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Rehmannia interact with medications?

No drug interactions are recorded for Rehmannia in our sources. This does not rule them out — check with a pharmacist.

Is Rehmannia a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 Rehmannioside A alleviates neuroinflammation and cognitive impairments after traumatic brain injury by suppressing microglial activation via the MAPK/NF-κB pathway. literature abstract metadata
  2. T2 A multidimensional integrated strategy for identifying anti-thrombotic quality markers(Q-Markers) in Taohong Siwu decoction through combined analysis of chemical profiling, bioactivity, and pharmacodynamic efficacy. literature abstract metadata
  3. T2 Sanwu Huangqin decoction induces ferroptosis in colorectal cancer cells by triggering NCOA4/FTH1-mediated ferritinophagy. literature abstract metadata
  4. T2 Rehmannioside D prevents estrogen-deficiency induced osteoporosis by interacting with c-Jun to dismantle the AP-1 complex and suppress MAPK/NF-κB signaling. literature abstract metadata
  5. T3 Rehmannia CC BY-SA 4.0

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