Chinese-foxglove
Rehmannia glutinosa
Rehmannia glutinosa, a traditional Chinese medicinal plant also known as dihuang, is used in various herbal remedies. Its use primarily revolves around its purported benefits for blood and yin tonification, although specific traditional uses are not extensively documented. Scientific evidence suggests potential health benefits such as preventing estrogen-deficiency-induced osteoporosis through mechanisms involving the inhibition of osteoclastogenesis and induction of their apoptosis. Additionally, Rehmannia glutinosa has shown promise in suppressing colorectal cancer cell proliferation via a NCOA4/FTH1 pathway activation mechanism. The Taohong Siwu Decoction derived from this plant has identified six key components that may serve as quality markers for its antithrombotic effects. Furthermore, Rehmannia glutinosa treatment improved cognitive functions and reduced neuronal loss in mice subjected to traumatic brain injury (TBI) by suppressing microglial activation. To date, no significant safety concerns or drug interactions have been recorded with this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- REA treatment improved cognitive functions and reduced neuronal loss in TBI mice by suppressing microglial activation.
- Rehmannioside D prevents estrogen-deficiency-induced osteoporosis by inhibiting osteoclastogenesis and inducing their apoptosis through dual mechanisms.
- SWHQD suppresses colorectal cancer through NCOA4/FTH1-mediated ferritinophagy-induced ferroptosis.
- This study identified six key components in Rehmannia glutinosa-based Taohong Siwu Decoction as potential Q-Markers for its antithrombotic effects.
Frequently asked questions
What is Chinese-foxglove?
Chinese-foxglove (Rehmannia glutinosa) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Chinese-foxglove?
4 sourced findings are recorded for Chinese-foxglove; the strongest carries evidence grade D. For example: REA treatment improved cognitive functions and reduced neuronal loss in TBI mice by suppressing microglial activation.
How strong is the evidence for Chinese-foxglove?
The strongest finding for Chinese-foxglove carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Chinese-foxglove safe? What are the side effects?
No major safety issues are recorded for Chinese-foxglove in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Chinese-foxglove interact with medications?
No drug interactions are recorded for Chinese-foxglove in our sources. This does not rule them out — check with a pharmacist.
Is Chinese-foxglove a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Rehmannioside A alleviates neuroinflammation and cognitive impairments after traumatic brain injury by suppressing microglial activation via the MAPK/NF-κB pathway. literature abstract metadata
- T2 A multidimensional integrated strategy for identifying anti-thrombotic quality markers(Q-Markers) in Taohong Siwu decoction through combined analysis of chemical profiling, bioactivity, and pharmacodynamic efficacy. literature abstract metadata
- T2 Sanwu Huangqin decoction induces ferroptosis in colorectal cancer cells by triggering NCOA4/FTH1-mediated ferritinophagy. literature abstract metadata
- T2 Rehmannioside D prevents estrogen-deficiency induced osteoporosis by interacting with c-Jun to dismantle the AP-1 complex and suppress MAPK/NF-κB signaling. literature abstract metadata