Chinese-foxglove
Rehmannia glutinosa
Rehmannia glutinosa, a traditional Chinese medicinal plant commonly used in herbal remedies, has a long-standing tradition within Eastern medicine. Traditionally, it is believed to be beneficial for conditions such as kidney deficiency and blood disorders, though specific uses are not extensively documented. Scientific evidence suggests potential benefits including improved cognitive functions and reduced neuronal loss following traumatic brain injury (TBI) through mechanisms involving microglial activation suppression. Additionally, Rehmannia glutinosa has shown promise in preventing estrogen-deficiency-induced osteoporosis by inhibiting osteoclastogenesis and inducing their apoptosis via dual mechanisms. Furthermore, it appears to have anti-cancer properties, particularly against colorectal cancer, through NCOA4/FTH1-mediated ferritinophagy-induced ferroptosis. Six key components of Rehmannia glutinosa-based Taohong Siwu Decoction have been identified as potential quality markers for its antithrombotic effects. No major safety concerns or recorded drug interactions are currently known, though further research is necessary to fully understand its efficacy and safety profile.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- REA treatment improved cognitive functions and reduced neuronal loss in TBI mice by suppressing microglial activation.
- Rehmannioside D prevents estrogen-deficiency-induced osteoporosis by inhibiting osteoclastogenesis and inducing their apoptosis through dual mechanisms.
- SWHQD suppresses colorectal cancer through NCOA4/FTH1-mediated ferritinophagy-induced ferroptosis.
- This study identified six key components in Rehmannia glutinosa-based Taohong Siwu Decoction as potential Q-Markers for its antithrombotic effects.
Frequently asked questions
What is Chinese-foxglove?
Chinese-foxglove (Rehmannia glutinosa) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Chinese-foxglove?
4 sourced findings are recorded for Chinese-foxglove; the strongest carries evidence grade D. For example: REA treatment improved cognitive functions and reduced neuronal loss in TBI mice by suppressing microglial activation.
How strong is the evidence for Chinese-foxglove?
The strongest finding for Chinese-foxglove carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Chinese-foxglove safe? What are the side effects?
No major safety issues are recorded for Chinese-foxglove in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Chinese-foxglove interact with medications?
No drug interactions are recorded for Chinese-foxglove in our sources. This does not rule them out — check with a pharmacist.
Is Chinese-foxglove a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Rehmannioside A alleviates neuroinflammation and cognitive impairments after traumatic brain injury by suppressing microglial activation via the MAPK/NF-κB pathway. literature abstract metadata
- T2 A multidimensional integrated strategy for identifying anti-thrombotic quality markers(Q-Markers) in Taohong Siwu decoction through combined analysis of chemical profiling, bioactivity, and pharmacodynamic efficacy. literature abstract metadata
- T2 Sanwu Huangqin decoction induces ferroptosis in colorectal cancer cells by triggering NCOA4/FTH1-mediated ferritinophagy. literature abstract metadata
- T2 Rehmannioside D prevents estrogen-deficiency induced osteoporosis by interacting with c-Jun to dismantle the AP-1 complex and suppress MAPK/NF-κB signaling. literature abstract metadata