Siler
Saposhnikovia divaricata
Saposhnikovia divaricata, commonly known as Fang Feng in traditional Chinese medicine, originates from East Asia and has a long history of use. Traditionally, it is employed for its purported anti-inflammatory and immune-stimulating properties, though specific uses vary across different traditions. Scientific evidence suggests that compounds derived from Saposhnikovia divaricata may modulate M1 macrophage polarization and ameliorate rheumatoid arthritis (RA) by targeting CBLL1, although the exact mechanisms are not fully understood. Additionally, studies indicate potential renoprotective effects of Yupingfeng San extract in models of renal interstitial fibrosis through modulation of the IL-6/JAK/STAT3 pathway and mitochondrial homeostasis. Saposhnikovia divaricata-derived Prim-O-glucosylcimifugin has also shown promise in ameliorating RA by targeting GBP5 to suppress pyroptosis and inhibit synovial cell proliferation, though further research is needed to confirm these findings. To date, no major safety issues or drug interactions have been recorded for Saposhnikovia divaricata.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- CHR from Saposhnikovia divaricata modulate M1 macrophage polarization and ameliorate RA by targeting CBLL1, though the exact mechanism remains partially elucidated.
- Inoculation with Aspergillus neoalliaceus MR-86 increased Saposhnikovia divaricata growth and altered its rhizosphere microbiome.
- Yupingfeng San extract showed renoprotective effects in cisplatin-induced renal interstitial fibrosis by modulating IL-6/JAK/STAT3 pathway and mitochondrial homeostasis.
- Saposhnikovia divaricata-derived Prim-O-glucosylcimifugin ameliorates rheumatoid arthritis by targeting GBP5 to suppress pyroptosis and inhibit synovial cell proliferation.
Frequently asked questions
What is Siler?
Siler (Saposhnikovia divaricata) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Siler?
4 sourced findings are recorded for Siler; the strongest carries evidence grade D. For example: CHR from Saposhnikovia divaricata modulate M1 macrophage polarization and ameliorate RA by targeting CBLL1, though the exact mechanism remains partially elucidated.
How strong is the evidence for Siler?
The strongest finding for Siler carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Siler safe? What are the side effects?
No major safety issues are recorded for Siler in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Siler interact with medications?
No drug interactions are recorded for Siler in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Siler?
Siler is also known as: Сапожниковия растопыренная.
Is Siler a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Chromones from Saposhnikovia divaricata modulate m6A RNA methylation-mediated macrophage polarization by targeting CBLL1 to ameliorate RA. literature abstract metadata
- T2 Yupingfeng San extract ameliorates cisplatin induced renal interstitial fibrosis via IL-6/JAK/STAT3 mediated restoration of mitochondrial homeostasis. literature abstract metadata
- T2 Prim-O-glucosylcimifugin ameliorates rheumatoid arthritis by targeting GBP5 to suppress pyroptosis and inhibit synovial cell proliferation. literature abstract metadata
- T2 Aspergillus neoalliaceus MR-86 Promotes the Growth of Saposhnikovia divaricata by Regulating the Rhizosphere Microbiome. literature abstract metadata