Glabrous Sarcandra Herb
Sarcandra glabra
Sarcandra glabra is a plant traditionally used in Chinese medicine but lacks specific traditional uses documented for this species. Scientific evidence suggests that its polysaccharides may have immunomodulatory, anti-inflammatory, and antioxidant activities, potentially alleviating chronic kidney disease by inhibiting P2X7/PSME3-driven 20S proteasome hyperactivation. Total flavonoids from Sarcandra glabra also show significant suppression of K562 cell viability and promote apoptosis through effects on sphingolipid metabolism and inhibition of the PI3K/Akt signaling pathway, indicating possible anti-cancer properties. Tetrasargltones A and B, isolated compounds, exhibit cytotoxic activity against cancer cells by inhibiting the NF-κB pathway. No major safety issues or recorded drug interactions have been identified for Sarcandra glabra to date.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- TSA alleviates chronic kidney disease by inhibiting P2X7/PSME3-driven 20S proteasome hyperactivation.
- This review synthesizes the pharmacological evidence of S. glabra polysaccharides, linking traditional uses with modern findings on immunomodulatory, anti-inflammatory, and antioxidant activities.
- Total flavonoids from Sarcandra glabra significantly suppressed K562 cell viability and promoted apoptosis by affecting sphingolipid metabolism and inhibiting the PI3K/Akt signaling pathway.
- Tetrasargltones A and B, isolated from Sarcandra glabra, exhibit cytotoxic activity against cancer cell lines, with one compound inhibiting the NF-κB pathway.
Frequently asked questions
What is Glabrous Sarcandra Herb?
Glabrous Sarcandra Herb (Sarcandra glabra) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Glabrous Sarcandra Herb?
4 sourced findings are recorded for Glabrous Sarcandra Herb; the strongest carries evidence grade A. For example: TSA alleviates chronic kidney disease by inhibiting P2X7/PSME3-driven 20S proteasome hyperactivation.
How strong is the evidence for Glabrous Sarcandra Herb?
The strongest finding for Glabrous Sarcandra Herb carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Glabrous Sarcandra Herb safe? What are the side effects?
No major safety issues are recorded for Glabrous Sarcandra Herb in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Glabrous Sarcandra Herb interact with medications?
No drug interactions are recorded for Glabrous Sarcandra Herb in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Glabrous Sarcandra Herb?
Glabrous Sarcandra Herb is also known as: Саркандра голая.
Is Glabrous Sarcandra Herb a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 A review of Sarcandra glabra (Thunb.) Nakai polysaccharides: Extraction, structural characteristics, pharmacology, and structure-activity relationships. literature abstract metadata
- T2 [Total flavonoids from Sarcandra glabra promote apoptosis in leukemia K562 cells via sphingolipid metabolism and PI3K/Akt signaling pathway based on cellular metabolomics]. literature abstract metadata
- T2 Trishizukaol A alleviates chronic kidney disease by restraining P2X7/PSME3-driven 20S proteasome hyperactivation. literature abstract metadata
- T2 Tetrasargltones A and B, Fully Helically Polymerized Lindenane Sesquiterpenoid Tetramers from Sarcandra glabra. literature abstract metadata