Blue Skullcap
Scutellaria lateriflora
Scutellaria lateriflora, commonly known as American skullcap, originates from North America. While traditionally used in Native American and Chinese medicine for various ailments including nervousness and fever, specific traditional uses for S. lateriflora are not well-documented. Scientific evidence suggests that a Scutellaria lateriflora extract-based food supplement may improve sleep parameters without adverse effects in individuals with mild to moderate primary insomnia. Additionally, the ethanol extract improved sleep in older male flies, while both aqueous and ethanol extracts enhanced mobility. A 3-month intervention with chewing gums containing S. lateriflora and C. incanus extracts showed a significant improvement in gingival health compared to placebo. The review also highlights baicalein's pharmacokinetics, pharmacodynamics, and strategies to enhance its low oral bioavailability. Notably, no major safety issues or drug interactions have been recorded for S. lateriflora, though further research is needed to confirm these findings comprehensively.
- Best evidence
- B
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- A Scutellaria lateriflora extract-based food supplement showed significant improvement in sleep parameters without adverse effects in individuals with mild to moderate primary insomnia.
- Scutellaria lateriflora ethanol extract improved sleep in older male flies, while both aqueous and ethanol extracts enhanced mobility.
- The study found that using chewing gum containing Scutellaria lateriflora and Cistus × incanus extracts led to significant improvements in gingival health compared to a placebo after 3 months.
- The study reviews baicalein's pharmacokinetics, pharmacodynamics, and strategies to enhance its oral bioavailability in Scutellaria lateriflora.
Frequently asked questions
What is Blue Skullcap?
Blue Skullcap (Scutellaria lateriflora) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Blue Skullcap?
4 sourced findings are recorded for Blue Skullcap; the strongest carries evidence grade B. For example: A Scutellaria lateriflora extract-based food supplement showed significant improvement in sleep parameters without adverse effects in individuals with mild to moderate primary insomnia.
How strong is the evidence for Blue Skullcap?
The strongest finding for Blue Skullcap carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Blue Skullcap safe? What are the side effects?
No major safety issues are recorded for Blue Skullcap in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Blue Skullcap interact with medications?
No drug interactions are recorded for Blue Skullcap in our sources. This does not rule them out — check with a pharmacist.
Is Blue Skullcap a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Efficacy and Tolerability of a Scutellaria lateriflora L. and Cistus × incanus L.-Based Chewing Gum on the Symptoms of Gingivitis: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. literature abstract metadata
- T2 Efficacy and Tolerability of a Chemically Characterized Scutellaria lateriflora L. Extract-Based Food Supplement for Sleep Management: A Single-Center, Controlled, Randomized, Crossover, Double-Blind Clinical Trial. literature abstract metadata
- T2 Scutellaria lateriflora Extract Supplementation Provides Resilience to Age-Related Phenotypes in Drosophila melanogaster. literature abstract metadata
- T2 Pharmacokinetics, pharmacodynamics and formulation strategies for enhanced bioavailability of baicalein: an update. literature abstract metadata