American Sicklepod
Senna obtusifolia
Senna obtusifolia, a traditional plant used in various Middle Eastern and North African herbal practices, has not been extensively documented for specific medicinal uses. Scientific evidence suggests that its active compound, obtusifolin, may reduce inflammation and tissue injury by modulating NFκB signaling pathways, particularly in models of acute pancreatitis. Additionally, Senna obtusifolia exhibits antifungal and insecticidal properties, though these findings are based on comparative studies with other plants. In liver fibrosis research, an extract from the plant attenuated CCl4-induced liver fibrosis by modulating the ROCK2/Cofilin-1/NFκB pathway. No major safety concerns or recorded drug interactions have been identified for Senna obtusifolia to date.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Obtusifolin treatment reduced inflammation and tissue injury in both in vitro and in vivo models of acute pancreatitis by modulating NFκB signaling.
- Senna obtusifolia showed antifungal and insecticidal properties in laboratory conditions among other plants reviewed.
- SaintGSE analysis identified key OA-related signaling pathways potentially modulated by natural extract from Senna obtusifolia.
- OBT treatment attenuated CCl4-induced liver fibrosis by modulating the ROCK2/Cofilin-1/NFκB pathway in both in vitro and in vivo models.
- Sicklepod (Senna obtusifolia) ingestion caused muscle weakness and myofiber degeneration in goats, leading to myopathy.
Frequently asked questions
What is American Sicklepod?
American Sicklepod (Senna obtusifolia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about American Sicklepod?
5 sourced findings are recorded for American Sicklepod; the strongest carries evidence grade D. For example: Obtusifolin treatment reduced inflammation and tissue injury in both in vitro and in vivo models of acute pancreatitis by modulating NFκB signaling.
How strong is the evidence for American Sicklepod?
The strongest finding for American Sicklepod carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is American Sicklepod safe? What are the side effects?
No major safety issues are recorded for American Sicklepod in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does American Sicklepod interact with medications?
No drug interactions are recorded for American Sicklepod in our sources. This does not rule them out — check with a pharmacist.
What are the common names of American Sicklepod?
American Sicklepod is also known as: Casse fétide.
Is American Sicklepod a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Toxic myopathy in dairy goats caused by spontaneous ingestion of Senna obtusifolia. literature abstract metadata
- T2 Obtusifolin mitigates CCl4-induced inflammation and liver fibrosis by modulating the ROCK2/ Cofilin-1 / NFκB pathway. literature abstract metadata
- T2 Obtusifolin ameliorates pancreatic tissue injury and inflammation by modulating the NFκB signaling. literature abstract metadata
- T2 SaintGSE: Transformer-based efficient and explainable gene set enrichment analysis. literature abstract metadata
- T2 Medicinal Plants as Biopesticides Against Pests and Diseases of Maize (Zea mays L.) in Africa: Ethnobotanical Insights and Challenges. literature abstract metadata