Trigonostemon
Trigonostemon
Trigonostemon is a genus of plants with traditional medicine roots primarily in Southeast Asia, though specific uses for these plants are not well-documented. Scientific research has shown that extracts from Trigonostemon xyphophyllorides exhibit significant anti-proliferative effects on renal cancer cells through the PI3K-AKT pathway. Additionally, Trigonochinene E from Strophioblachia fimbricalyx promotes lysosomal biogenesis and enhances autophagy via TFEB/TFE3 in degenerative NP cells. Two novel rearranged norditerpenoids identified from this genus have shown some proliferation inhibition and neuroprotective activity. The active component, PSO, also demonstrates potent antiproliferative effects on renal cell carcinoma cells by inhibiting the PI3K/AKT pathway. To date, no major safety issues or drug interactions have been recorded for these compounds, but further research is needed to fully understand their potential benefits and risks.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study found that Trigonostemon xyphophyllorides extract showed significant anti-proliferative effects on renal cancer cells via the PI3K-AKT pathway.
- Trigonochinene E promotes lysosomal biogenesis and enhances autophagy via TFEB/TFE3 in human degenerative NP cells.
- Two novel rearranged norditerpenoids with unique tricyclic structures were identified from Strophioblachia fimbricalyx, showing some proliferation inhibition and neuroprotective activity.
- PSO, an active component of Trigonostemon xyphophyllorides, showed potent antiproliferative effects on renal cell carcinoma cells through PI3K/AKT pathway inhibition.
- Two total syntheses of trigoxyphins K and L from Trigonostemon xyphophylloides are described.
Frequently asked questions
What is Trigonostemon?
Trigonostemon (Trigonostemon) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Trigonostemon?
5 sourced findings are recorded for Trigonostemon; the strongest carries evidence grade D. For example: The study found that Trigonostemon xyphophyllorides extract showed significant anti-proliferative effects on renal cancer cells via the PI3K-AKT pathway.
How strong is the evidence for Trigonostemon?
The strongest finding for Trigonostemon carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Trigonostemon safe? What are the side effects?
No major safety issues are recorded for Trigonostemon in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Trigonostemon interact with medications?
No drug interactions are recorded for Trigonostemon in our sources. This does not rule them out — check with a pharmacist.
Is Trigonostemon a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Trigonochinene E promotes lysosomal biogenesis and enhances autophagy via TFEB/TFE3 in human degenerative NP cells against oxidative stress. literature abstract metadata
- T2 Strophiofimbrins A and B: Two Rearranged Norditerpenoids with Novel Tricyclic Carbon Skeletons from Strophioblachia fimbricalyx. literature abstract metadata
- T2 Two Total Syntheses of Trigoxyphins K and L. literature abstract metadata
- T2 Antiproliferative effects of Trigonostemon xyphophyllorides on renal cell carcinoma via the PI3K/AKT pathway. literature abstract metadata
- T2 Multi-omics analysis reveals psoralen to suppresses renal cell carcinoma through the PI3K/AKT pathway. literature abstract metadata