small-fruit wild frangipani
Voacanga africana
Voacanga africana is a traditional plant primarily associated with West African herbal medicine traditions, though specific uses are not well-documented. Scientific investigations have revealed several alkaloids from its root bark, including voacandial and voacanginone A, which were isolated recently. Voagafries B and E showed significant cytotoxicity against SH-SY5Y cells, while seven alkaloids isolated demonstrated antiplasmodial activity with IC50 values ranging between 5.734 ± 1.365 and 5.319 ± 2.206 µg/mL for voacamine (2) and voacorine (3), respectively. However, the current scientific evidence is limited, and more research is needed to fully understand its potential medicinal applications. No major safety concerns or recorded drug interactions have been identified thus far.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Alkaloids voacamine (2) and voacorine (3) from Voacanga africana showed good in vitro antiplasmodial activity with IC50 values of 5.734 ± 1.365 and 5.319 ± 2.206 µg/mL, respectively.
- Seven alkaloids were isolated from Voacanga africana, with two found to inhibit E. coli biofilms.
- Voagafries B and E from Voacanga africana showed significant cytotoxicity against SH-SY5Y cells.
- Two new iboga-type monoterpenoid indole alkaloids, voacandial and voacanginone A, were isolated from Voacanga africana root bark.
Frequently asked questions
What is small-fruit wild frangipani?
small-fruit wild frangipani (Voacanga africana) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about small-fruit wild frangipani?
4 sourced findings are recorded for small-fruit wild frangipani; the strongest carries evidence grade D. For example: Alkaloids voacamine (2) and voacorine (3) from Voacanga africana showed good in vitro antiplasmodial activity with IC50 values of 5.734 ± 1.365 and 5.319 ± 2.206 µg/mL, respectively.
How strong is the evidence for small-fruit wild frangipani?
The strongest finding for small-fruit wild frangipani carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is small-fruit wild frangipani safe? What are the side effects?
No major safety issues are recorded for small-fruit wild frangipani in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does small-fruit wild frangipani interact with medications?
No drug interactions are recorded for small-fruit wild frangipani in our sources. This does not rule them out — check with a pharmacist.
What are the common names of small-fruit wild frangipani?
small-fruit wild frangipani is also known as: Воаканга африканская, voacanga d'Afrique.
Is small-fruit wild frangipani a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Spirooxindol alkaloids from Voacanga africana: Targeting biofilm of MBLs producing Escherichia coli. literature abstract metadata
- T2 Voagafries A-E, undescribed indole alkaloids with anti-glioma activity from Voacanga africana. literature abstract metadata
- T2 Voacandial and Voacanginone A, Iboga-Type Monoterpenoid Indole Alkaloids from Voacanga africana Root Bark: Isolation, Structure Elucidation, and Asymmetric Total Syntheses. literature abstract metadata
- T2 Iboga-Indole Alkaloids as Potential Plasmodial Inhibitors: Identification, Biosynthesis, and Molecular Docking Studies. literature abstract metadata