armoise de Douglas
Artemisia douglasiana · California mugwort
Artemisia douglasiana is a plant traditionally found in North America. While it has not been extensively used in traditional medicine, studies have shown that dehydroleucodine, a compound derived from this plant, exhibited dose-dependent lethality to Bufo arenarum embryos and cytotoxicity against both normal human cells and breast cancer cell lines. Additionally, treatment with dehydroleucodine induced DNA damage leading to senescence or apoptosis in cancer cells. In mice, dehydroleucodine also delayed intestinal transit, which may be mediated through interaction with the α2-adrenergic receptor. No major safety issues or drug interactions have been recorded for Artemisia douglasiana; however, further research is needed to fully understand its potential effects and applications.
- Meilleure preuve
- D
- Précautions
- —
Information uniquement. L'usage traditionnel ne signifie pas une efficacité prouvée. Les preuves et la sécurité varient — consultez les sources citées.
Ce que dit la science
- La déhydrolevocodine a montré une toxicité dose-dépendante chez les embryons de Bufo arenarum, avec des concentrations plus élevées étant plus dangereuses.
- Les extraits éthyliques et aqueux d'Artemisia douglasiana ont montré une cytoxicité chez les cellules humaines normales ainsi que chez les lignées cellulaires du cancer du sein.
- La déhydroléucodine d'Artemisia douglasiana a ralenti le transit intestinal chez les souris, potentiellement par l'intermédiaire d'une interaction avec le récepteur adrénergique alpha-2.
- Le traitement par dehydroleucodine induit un dommage au DNA, une sénescence ou une apoptose chez les cellules cancéreuses selon la concentration.
Frequently asked questions
What is armoise de Douglas?
armoise de Douglas (Artemisia douglasiana) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about armoise de Douglas?
4 sourced findings are recorded for armoise de Douglas; the strongest carries evidence grade D. For example: La déhydrolevocodine a montré une toxicité dose-dépendante chez les embryons de Bufo arenarum, avec des concentrations plus élevées étant plus dangereuses.
How strong is the evidence for armoise de Douglas?
The strongest finding for armoise de Douglas carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is armoise de Douglas safe? What are the side effects?
No major safety issues are recorded for armoise de Douglas in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does armoise de Douglas interact with medications?
No drug interactions are recorded for armoise de Douglas in our sources. This does not rule them out — check with a pharmacist.
What are the common names of armoise de Douglas?
armoise de Douglas is also known as: California mugwort, Полынь Дугласа.
Is armoise de Douglas a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Effect of dehydroleucodine on intestinal transit: structural basis of the interaction with the α(2)-adrenergic receptor. literature abstract metadata
- T2 Lethal effect of dehydroleucodine (DhL) on amphibian Bufo arenarum embryos. literature abstract metadata
- T2 The sesquiterpene lactone dehydroleucodine triggers senescence and apoptosis in association with accumulation of DNA damage markers. literature abstract metadata
- T2 Ethanolic Extracts of California Mugwort (Artemisia douglasiana Besser) Are Cytotoxic against Normal and Cancerous Human Cells. literature abstract metadata