Shrubby sophora
Sophora flavescens
Sophora flavescens，又称 Kushen 或 Huai Shen，是一种传统的中国草药植物。它在各种传统中药配方中被使用了几个世纪，但其具体的传统用途并未详细记录。科学证据表明，SWHQD（从 Sophora flavescens 提取的化合物）可以通过 NCOA4/FTH1 介导的铁蛋白自噬诱导和铁死亡来抑制结直肠癌。此外，Kushenol E 可以通过抑制微胶质细胞 IDO1 活性减轻与败血症相关的认知功能障碍。另外，SFG（Sophora flavescens 糖苷）在小鼠 DSS 诱导的溃疡性结肠炎中显示出缓解炎症并恢复紧密连接蛋白和肠道微生物群的潜力。另一种化合物 Matrine 可以通过 JAK2-STAT3 激活减少三酰甘油积累并促进 CPT1b 表达，从而改善心肌缺血再灌注损伤。
- 最佳证据
- D
- 注意事项
- —
仅供参考。传统用法并不代表已被证实有效。证据与安全性各不相同，请查阅所引来源。
科学怎么说
- SWHQD通过NCOA4/FTH1介导的铁蛋白自噬引起的铁死亡来抑制结肠癌。
- 从 Sophora flavescens 中提取的 Kushenol E 减轻与败血症相关的认知功能障碍，通过抑制小胶质细胞中的 IDO1 活性。
- SFG 可减轻由DSS诱导的小鼠溃疡性结肠炎，通过抑制炎症并恢复紧密连接蛋白和肠道微生物群。
- 马特林通过激活JAK2-STAT3途径减少甘油三酯积累并促进CPT1b表达，从而改善心肌缺血再灌注损伤。
Frequently asked questions
What is Shrubby sophora?
Shrubby sophora (Sophora flavescens) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Shrubby sophora?
4 sourced findings are recorded for Shrubby sophora; the strongest carries evidence grade D. For example: SWHQD通过NCOA4/FTH1介导的铁蛋白自噬引起的铁死亡来抑制结肠癌。
How strong is the evidence for Shrubby sophora?
The strongest finding for Shrubby sophora carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Shrubby sophora safe? What are the side effects?
No major safety issues are recorded for Shrubby sophora in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Shrubby sophora interact with medications?
No drug interactions are recorded for Shrubby sophora in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Shrubby sophora?
Shrubby sophora is also known as: Софора желтоватая.
Is Shrubby sophora a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
来源
- T2 Kushenol E alleviates sepsis-associated cognitive dysfunction via microglial indoleamine 2,3-dioxygenase 1 inhibition. literature abstract metadata
- T2 Sanwu Huangqin decoction induces ferroptosis in colorectal cancer cells by triggering NCOA4/FTH1-mediated ferritinophagy. literature abstract metadata
- T2 Sophoraflavanone G alleviates ulcerative colitis in mice by reshaping the gut microbiome and restoring the Th17/Treg balance through the PI3K/AKT/NF-κB signaling pathway. literature abstract metadata
- T2 Matrine ameliorated myocardial ischemia-reperfusion injury through lipid accumulation reduction by activating JAK2-STAT3-CPT1 signaling pathway. literature abstract metadata