Shrubby sophora
Sophora flavescens
Sophora flavescens is a perennial herb central to various East Asian medicinal traditions. It is traditionally employed to address conditions such as dysentery, jaundice, fever, diarrhea, and various bacterial infections, often acting as an astringent or diuretic. Preliminary scientific evidence suggests potential therapeutic mechanisms, such as the ability of certain extracts to suppress colorectal cancer cells through ferroptosis, mitigate sepsis-associated cognitive dysfunction, alleviate ulcerative colitis in murine models, and reduce myocardial ischemia-reperfusion injury. No major safety issues or notable drug interactions are currently recorded in the available data.
- Traditionally for
- dysentery · jaundice
- Traditions
- TCM · Japanese (Kampo) · traditional
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
Traditional use
- dysentery
- jaundice
- stomachic
- diarrhea
- fever
- hemorrhoids
- scrofula
- alexiteric
- astringent
- bacterial infections
- carbuncle
- carminative
- diuretic
- enteritis
- enterorrhagia
What the science says
- SWHQD suppresses colorectal cancer through NCOA4/FTH1-mediated ferritinophagy-induced ferroptosis.
- Kushenol E from Sophora flavescens mitigates sepsis-associated cognitive dysfunction by inhibiting microglial IDO1 activity.
- SFG alleviates DSS-induced ulcerative colitis in mice by suppressing inflammation and restoring tight junction proteins and the gut microbiome.
- Matrine improved myocardial ischemia-reperfusion injury by reducing triglyceride accumulation and promoting CPT1b expression through JAK2-STAT3 activation.
Frequently asked questions
What is Shrubby sophora?
Shrubby sophora (Sophora flavescens) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What is Shrubby sophora traditionally used for?
Traditional sources record Shrubby sophora for: dysentery, jaundice, stomachic, diarrhea, fever, hemorrhoids. This reflects traditional use, not a proven medical treatment.
Which traditions use Shrubby sophora?
Shrubby sophora appears in these traditions in our sources: TCM, Japanese (Kampo), traditional.
What does the scientific evidence say about Shrubby sophora?
4 sourced findings are recorded for Shrubby sophora; the strongest carries evidence grade D. For example: SWHQD suppresses colorectal cancer through NCOA4/FTH1-mediated ferritinophagy-induced ferroptosis.
How strong is the evidence for Shrubby sophora?
The strongest finding for Shrubby sophora carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Shrubby sophora safe? What are the side effects?
No major safety issues are recorded for Shrubby sophora in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Shrubby sophora interact with medications?
No drug interactions are recorded for Shrubby sophora in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Shrubby sophora?
Shrubby sophora is also known as: Софора желтоватая.
Is Shrubby sophora a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T3 Dr. Duke's Ethnobotanical Database public domain (USDA ARS — attribute Dr. Duke's)
- T2 Kushenol E alleviates sepsis-associated cognitive dysfunction via microglial indoleamine 2,3-dioxygenase 1 inhibition. literature abstract metadata
- T2 Sanwu Huangqin decoction induces ferroptosis in colorectal cancer cells by triggering NCOA4/FTH1-mediated ferritinophagy. literature abstract metadata
- T2 Sophoraflavanone G alleviates ulcerative colitis in mice by reshaping the gut microbiome and restoring the Th17/Treg balance through the PI3K/AKT/NF-κB signaling pathway. literature abstract metadata
- T2 Matrine ameliorated myocardial ischemia-reperfusion injury through lipid accumulation reduction by activating JAK2-STAT3-CPT1 signaling pathway. literature abstract metadata